2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- Product Name
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- CAS No.
- 5198-86-7
- Chemical Name
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- Synonyms
- 2-BROMOTHIAZOLE-4-METHANOL;2-Bromo-4-thiazolemethanol;2-Bromo-4-thiazolylmethanol;4-ThiazoleMethanol,2-broMo-;(2-bromothiazol-4-yl)methanol;2-BROMO-4-HYDROXYMETHYLTHIAZOLE;(2-bromo-1,3-thiazol-4-yl)methanol;(2-BROMO-1,3-THIAZOLE-4-YL)METHANOL;2-Bromo-4-(hydroxymethyl)-1,3-thiazole;2-Bromo-4-(hydroxymethyl)-1,3-thiazole97%
- CBNumber
- CB5463116
- Molecular Formula
- C4H4BrNOS
- Formula Weight
- 194.05
- MOL File
- 5198-86-7.mol
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Property
- Boiling point:
- 56 °C(Press: 10 Torr)
- Density
- 1.899±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- liquid
- pka
- 12.82±0.10(Predicted)
- color
- Light yellow
- CAS DataBase Reference
- 5198-86-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00394
- Product name
- 2-Bromo-4-hydroxymethylthiazole
- Packaging
- 1g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- B688383
- Product name
- 2-Bromothiazole-4-methanol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B688383
- Product name
- 2-Bromothiazole-4-methanol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 8H01-9-X0
- Product name
- 2-Bromo-4-(hydroxymethyl)-1,3-thiazole
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 069441
- Product name
- 2-Bromo-4-hydroxymethylthiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $331
- Updated
- 2021/12/16
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production
Synthesis
100367-77-9
5198-86-7
General procedure for the synthesis of 2-bromothiazole-4-methanol from ethyl 2-bromothiazole-4-carboxylate: In a dry reaction flask, ethyl 2-bromothiazole-4-carboxylate (10.0 g, 42.4 mmol, 1 eq.) was dissolved in tetrahydrofuran (200 mL), and sodium borohydride (4.81 g, 127 mmol, 3 eq.), lithium chloride (5.4 g, 130 mmol, 3 eq.), and water (40 mL) were added in sequence. 130 mmol, 3 equiv) and water (40 mL). The resulting two-phase mixture was stirred vigorously at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 20% ethyl acetate/hexane) to confirm complete consumption of the raw materials. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (200 mL), diluted with the addition of ethyl acetate (200 mL), and the organic and aqueous layers were separated. The aqueous layer was extracted with ethyl acetate (100 mL), the organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-bromothiazole-4-methanol as a yellow semi-solid (7.82 g, 95% yield). The Rf value of the thin-layer chromatography was 0.2 (silica gel plate, unfolding agent was 20% ethyl acetate/hexane); the 1H NMR and 13C NMR spectra of the product were consistent with those reported in the literature (Wipf and Wang, 2007).
References
[1] Patent: WO2015/57585, 2015, A1. Location in patent: Page/Page column 27; 28
[2] Patent: CN104478866, 2017, B. Location in patent: Paragraph 0281; 0283; 0284
[3] Patent: CN104478869, 2017, B. Location in patent: Paragraph 0142; 0143; 0144; 0145
[4] Patent: WO2017/184624, 2017, A1. Location in patent: Page/Page column 185; 186
[5] Journal of Organic Chemistry, 2016, vol. 81, # 21, p. 10302 - 10320
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-4-HYDROXYMETHYLTHIAZOLE manufacturers
- Product
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 5198-86-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02