Ethyl 2-bromothiazole-4-carboxylate
- Product Name
- Ethyl 2-bromothiazole-4-carboxylate
- CAS No.
- 100367-77-9
- Chemical Name
- Ethyl 2-bromothiazole-4-carboxylate
- Synonyms
- ETHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE;ethyl 2-bromo-4-thiazolecarboxylate;ethyl 2-broMo-thiazol-4-carboxylate;Ethyl2-Bromothiazole-4-carboxylate>Ethyl2-bromothiazole-4-carboxylate,97%;2-Bromo-4-(ethoxycarbonyl)-1,3-thiazole;Ethyl 2-bromothiazole-4-carboxylate 96%;Ethyl 2-Bromothiazole-4-Carboxylate SKY;ethyl 2-bromo-1,3-thiazole-4-carboxylate;2-bromo-4-thiazolecarboxylic acid ethyl ester
- CBNumber
- CB8173805
- Molecular Formula
- C6H6BrNO2S
- Formula Weight
- 236.09
- MOL File
- 100367-77-9.mol
Ethyl 2-bromothiazole-4-carboxylate Property
- Melting point:
- 67-71 °C
- Boiling point:
- 154°C/13mmHg(lit.)
- Density
- 1.654±0.06 g/cm3(Predicted)
- Flash point:
- >110℃
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -1.50±0.10(Predicted)
- color
- White to Almost white
- Sensitive
- Moisture & Light Sensitive
- InChI
- InChI=1S/C6H6BrNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
- InChIKey
- CNHISCQPKKGDPO-UHFFFAOYSA-N
- SMILES
- S1C=C(C(OCC)=O)N=C1Br
- CAS DataBase Reference
- 100367-77-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 2
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT
- HS Code
- 29341000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 708429
- Product name
- Ethyl 2-bromothiazole-4-carboxylate
- Purity
- 96%
- Packaging
- 1g
- Price
- $95.5
- Updated
- 2023/01/07
- Product number
- E0900
- Product name
- Ethyl 2-Bromothiazole-4-carboxylate
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- E0900
- Product name
- Ethyl 2-Bromothiazole-4-carboxylate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $93
- Updated
- 2025/07/31
- Product number
- E0900
- Product name
- Ethyl 2-Bromothiazole-4-carboxylate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $265
- Updated
- 2025/07/31
- Product number
- E900913
- Product name
- Ethyl 2-bromothiazole-4-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
Ethyl 2-bromothiazole-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Ethyl 2-bromothiazole-4-carboxylate is an essential organic reagent that can be used as a building block for the synthesis of many organic compounds, such as 4-Thiazolecarboxylic acid, Ethyl thiazole-4-carboxylate， 2-Bromothiazole-4-carboxylic acid and so on.
Synthesis
5398-36-7
100367-77-9
Ethyl 2-aminothiazole-4-carboxylate (100 g, 581 mmol) and copper(II) bromide (195 g, 871 mmol) were dissolved in acetonitrile (1000 ml) at 0 °C. Subsequently, tert-butyl nitrite (104 ml, 871 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction mixture was diluted with a mixture of ethyl acetate (1000 ml) and water (3000 ml) and the pH was adjusted to 2 with 1 N hydrochloric acid.The organic and aqueous layers were separated, and the aqueous layer was extracted three times with ethyl acetate (500 ml). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from hexane to give pure ethyl 2-bromothiazole-4-carboxylate (115 g, 84% yield). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 8.52 (s, 1H), 4.29 (q, J=7.1 Hz, 2H), 1.29 (t, J=7.1 Hz, 3H). Mass spectral analysis showed m/z 235.90 [M+1].
References
[1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 2766 - 2775
[2] Zh. Obshch. Khim., 2017, vol. 87, # 12, p. 1947 - 1956,10
[3] Patent: WO2018/193387, 2018, A1. Location in patent: Page/Page column 92
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 2, p. 533 - 536
[5] Patent: US6468979, 2002, B1
Ethyl 2-bromothiazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-bromothiazole-4-carboxylate manufacturers
- Product
- Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-06-26
- Product
- Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-07