Ethyl 2-bromothiazole-4-carboxylate

Product Name: Ethyl 2-bromothiazole-4-carboxylate
CAS No.: 100367-77-9
Chemical Name: Ethyl 2-bromothiazole-4-carboxylate
Synonyms: ETHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE;ethyl 2-bromo-4-thiazolecarboxylate;ethyl 2-broMo-thiazol-4-carboxylate;Ethyl2-Bromothiazole-4-carboxylate>Ethyl2-bromothiazole-4-carboxylate,97%;2-Bromo-4-(ethoxycarbonyl)-1,3-thiazole;Ethyl 2-bromothiazole-4-carboxylate 96%;Ethyl 2-Bromothiazole-4-Carboxylate SKY;ethyl 2-bromo-1,3-thiazole-4-carboxylate;2-bromo-4-thiazolecarboxylic acid ethyl ester
CBNumber: CB8173805
Molecular Formula: C6H6BrNO2S
Formula Weight: 236.09
MOL File: 100367-77-9.mol

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Ethyl 2-bromothiazole-4-carboxylate Property

Melting point:: 67-71 °C
Boiling point:: 154°C/13mmHg(lit.)
Density: 1.654±0.06 g/cm3(Predicted)
Flash point:: >110℃
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: -1.50±0.10(Predicted)
color: White to Almost white
Sensitive: Moisture & Light Sensitive
InChI: InChI=1S/C6H6BrNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
InChIKey: CNHISCQPKKGDPO-UHFFFAOYSA-N
SMILES: S1C=C(C(OCC)=O)N=C1Br
CAS DataBase Reference: 100367-77-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-24/25
WGK Germany: 2
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708429
Product name: Ethyl 2-bromothiazole-4-carboxylate
Purity: 96%
Packaging: 1g
Price: $95.5
Updated: 2023/01/07

TCI Chemical

Product number: E0900
Product name: Ethyl 2-Bromothiazole-4-carboxylate
Purity: >95.0%(GC)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: E0900
Product name: Ethyl 2-Bromothiazole-4-carboxylate
Purity: >95.0%(GC)
Packaging: 5g
Price: $93
Updated: 2025/07/31

TCI Chemical

Product number: E0900
Product name: Ethyl 2-Bromothiazole-4-carboxylate
Purity: >95.0%(GC)
Packaging: 25g
Price: $265
Updated: 2025/07/31

TRC

Product number: E900913
Product name: Ethyl 2-bromothiazole-4-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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Ethyl 2-bromothiazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Ethyl 2-bromothiazole-4-carboxylate is an essential organic reagent that can be used as a building block for the synthesis of many organic compounds, such as 4-Thiazolecarboxylic acid, Ethyl thiazole-4-carboxylate， 2-Bromothiazole-4-carboxylic acid and so on.

Synthesis

5398-36-7

100367-77-9

Ethyl 2-aminothiazole-4-carboxylate (100 g, 581 mmol) and copper(II) bromide (195 g, 871 mmol) were dissolved in acetonitrile (1000 ml) at 0 °C. Subsequently, tert-butyl nitrite (104 ml, 871 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction mixture was diluted with a mixture of ethyl acetate (1000 ml) and water (3000 ml) and the pH was adjusted to 2 with 1 N hydrochloric acid.The organic and aqueous layers were separated, and the aqueous layer was extracted three times with ethyl acetate (500 ml). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from hexane to give pure ethyl 2-bromothiazole-4-carboxylate (115 g, 84% yield). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 8.52 (s, 1H), 4.29 (q, J=7.1 Hz, 2H), 1.29 (t, J=7.1 Hz, 3H). Mass spectral analysis showed m/z 235.90 [M+1].

References

[1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 2766 - 2775
[2] Zh. Obshch. Khim., 2017, vol. 87, # 12, p. 1947 - 1956,10
[3] Patent: WO2018/193387, 2018, A1. Location in patent: Page/Page column 92
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 2, p. 533 - 536
[5] Patent: US6468979, 2002, B1

Ethyl 2-bromothiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-bromothiazole-4-carboxylate Suppliers

Americas 1 Canada 1 China 236 Europe 1 Germany 3 India 20 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 7 United States 36 Global 309

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View Lastest Price from Ethyl 2-bromothiazole-4-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

PNP Biotech Co. Ltd

Product: Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-06-26

Career Henan Chemical Co

Product: Ethyl 2-bromothiazole-4-carboxylate 100367-77-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-07

100367-77-9, Ethyl 2-bromothiazole-4-carboxylateRelated Search:

RESMETHRIN Tris(trimethylsilyl)phosphate Benzocaine Urethane ISOXADIFEN-ETHYL 2-Ethoxyethanol Ethyl acetate 2-Bromothiazole Ethylparaben Ethanol Ethyl formate 4-Thiazolecarboxylic acid Trinexapac-ethyl METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE Ethyl 2-aminothiazole-4-carboxylate hydrochloride Ethyl 2-amino-1,3-thiazole-4-carboxylate 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Diethyl ether

ETHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE

2-BROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-bromothiazole-4-carboxylate 96%

ethyl 2-bromo-1,3-thiazole-4-carboxylate

Ethyl 2-Bromothiazole-4-Carboxylate SKY

ethyl 2-bromo-4-thiazolecarboxylate

2-Bromo-4-(ethoxycarbonyl)-1,3-thiazole

Ethyl2-bromothiazole-4-carboxylate,97%

2-bromo-4-thiazolecarboxylic acid ethyl ester

ethyl 2-broMo-thiazol-4-carboxylate

ethyl 2-bromothiazole-4-carboxylate, ethyl 2-bromo-4-thiazolecarboxylate, 2-bromo-4-(ethoxycarbonyl)thiazole, 2-bromo-thiazole-4-carboxylic acid ethyl ester, 2-bromothiazole-4-carboxylic acid ethyl ester, ethyl 2-bromo-1,3-thiazole-4-carboxylate, ethyl-2-bromo-thiazole-4-carboxylate

4-Thiazolecarboxylic acid, 2-bromo-, ethyl ester

Ethyl2-Bromothiazole-4-carboxylate&gt

100367-77-9 Ethyl 2-bromothiazole-4-carboxylate C6H6BrNO2S

4-Thiazolecarboxylic acid, 2-bromo-, ethyl ester (6CI, 9CI, ACI)

2-bromo-4-Thiazolecarboxylic acid ethyl ester (6CI 9CI ACI)

100367-77-9

100369-77-9

Thiazoles, Isothiazoles & Benzothiazoles

Building Blocks

Thiazole

Esters

Thiazoles, Isothiazoles &Benzothiazoles

Ethyl 2-Bromothiazole-4-Carboxylate SKY

blocks

Bromides

Carboxes

Thiazoles