2-BROMO-5-HYDROXYMETHYLTHIAZOLE
- Product Name
- 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
- CAS No.
- 687636-93-7
- Chemical Name
- 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
- Synonyms
- CAS:687636-93-7;RARECHEM AL BD 1435;2-BROMOTHIAZOLE-5-METHANOL;2-Bromo-5-thiazolemethanol;5-Thiazolemethanol, 2-bromo-;2-Bromo-5-hydromethylthiazole;(2-bromothiazol-5-yl)methanol;(2-bromo-5-thiazolyl)methanol;2-BROMO-5-HYDROXYMETHYLTHIAZOLE;(2-BROMO-1,3-THIAZOL-5-YL)METHANOL
- CBNumber
- CB8669339
- Molecular Formula
- C4H4BrNOS
- Formula Weight
- 194.05
- MOL File
- 687636-93-7.mol
2-BROMO-5-HYDROXYMETHYLTHIAZOLE Property
- Melting point:
- 46-48
- Boiling point:
- 288.3±15.0 °C(Predicted)
- Density
- 1.899±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder
- pka
- 13.23±0.10(Predicted)
- color
- Light yellow
- CAS DataBase Reference
- 687636-93-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00336
- Product name
- 2-Bromo-5-hydroxymethylthiazole
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- B688388
- Product name
- 2-Bromothiazole-5-methanol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- P000175268
- Product name
- 2-Bromothiazole-5-methanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 079893
- Product name
- 2-Bromothiazole-5-methanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- P000175268
- Product name
- 2-Bromothiazole-5-methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
2-BROMO-5-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production
Synthesis
464192-28-7
687636-93-7
General procedure for the synthesis of 2-bromothiazole-5-methanol from 2-bromo-5-formylthiazole: 2-bromothiazole-5-formaldehyde (3.00 g, 15.62 mmol) was mixed with methanol (50 mL). The mixture was cooled to 0 °C under nitrogen protection and sodium borohydride (0.591 g, 15.62 mmol) was added in batches. The reaction was stirred at this temperature for 2 hours. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. To the residue, saturated aqueous ammonium chloride solution was added, and the pH was adjusted to about 6 with 1 M aqueous hydrochloric acid, and then adjusted to about 10 with 1 M aqueous sodium hydroxide. the mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with saturated brine, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography eluting with a gradient of ethyl acetate/hexane (10% to 25%) to give 2-bromothiazole-5-methanol as a light yellow oil. Mass spectrum (DCI+) m/z 194,196 (M+H)+.
References
[1] Patent: WO2012/87833, 2012, A1. Location in patent: Page/Page column 125-126
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6303 - 6306
[3] Patent: WO2004/37818, 2004, A1. Location in patent: Page 69 - 70
[4] Patent: WO2007/75749, 2007, A2. Location in patent: Page/Page column 25; 37-39
[5] Patent: WO2009/77990, 2009, A1. Location in patent: Page/Page column 92
2-BROMO-5-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-HYDROXYMETHYLTHIAZOLE manufacturers
- Product
- 2-BROMO-5-HYDROXYMETHYLTHIAZOLE 687636-93-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08