ChemicalBook > CAS DataBase List > 2-BROMO-5-HYDROXYMETHYLTHIAZOLE

2-BROMO-5-HYDROXYMETHYLTHIAZOLE

Product Name: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
CAS No.: 687636-93-7
Chemical Name: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
Synonyms: CAS:687636-93-7;RARECHEM AL BD 1435;2-BROMOTHIAZOLE-5-METHANOL;2-Bromo-5-thiazolemethanol;5-Thiazolemethanol, 2-bromo-;2-Bromo-5-hydromethylthiazole;(2-bromothiazol-5-yl)methanol;(2-bromo-5-thiazolyl)methanol;2-BROMO-5-HYDROXYMETHYLTHIAZOLE;(2-BROMO-1,3-THIAZOL-5-YL)METHANOL
CBNumber: CB8669339
Molecular Formula: C4H4BrNOS
Formula Weight: 194.05
MOL File: 687636-93-7.mol

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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Property

Melting point:: 46-48
Boiling point:: 288.3±15.0 °C(Predicted)
Density: 1.899±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder
pka: 13.23±0.10(Predicted)
color: Light yellow
CAS DataBase Reference: 687636-93-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00336
Product name: 2-Bromo-5-hydroxymethylthiazole
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: B688388
Product name: 2-Bromothiazole-5-methanol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Ark Pharm

Product number: P000175268
Product name: 2-Bromothiazole-5-methanol
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Oakwood

Product number: 079893
Product name: 2-Bromothiazole-5-methanol
Purity: 98%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Ark Pharm

Product number: P000175268
Product name: 2-Bromothiazole-5-methanol
Purity: 97%
Packaging: 1g
Price: $50
Updated: 2021/12/16

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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production

Synthesis

464192-28-7

687636-93-7

General procedure for the synthesis of 2-bromothiazole-5-methanol from 2-bromo-5-formylthiazole: 2-bromothiazole-5-formaldehyde (3.00 g, 15.62 mmol) was mixed with methanol (50 mL). The mixture was cooled to 0 °C under nitrogen protection and sodium borohydride (0.591 g, 15.62 mmol) was added in batches. The reaction was stirred at this temperature for 2 hours. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. To the residue, saturated aqueous ammonium chloride solution was added, and the pH was adjusted to about 6 with 1 M aqueous hydrochloric acid, and then adjusted to about 10 with 1 M aqueous sodium hydroxide. the mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with saturated brine, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography eluting with a gradient of ethyl acetate/hexane (10% to 25%) to give 2-bromothiazole-5-methanol as a light yellow oil. Mass spectrum (DCI+) m/z 194,196 (M+H)+.

References

[1] Patent: WO2012/87833, 2012, A1. Location in patent: Page/Page column 125-126
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6303 - 6306
[3] Patent: WO2004/37818, 2004, A1. Location in patent: Page 69 - 70
[4] Patent: WO2007/75749, 2007, A2. Location in patent: Page/Page column 25; 37-39
[5] Patent: WO2009/77990, 2009, A1. Location in patent: Page/Page column 92

2-BROMO-5-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Suppliers

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View Lastest Price from 2-BROMO-5-HYDROXYMETHYLTHIAZOLE manufacturers

Career Henan Chemical Co

Product: 2-BROMO-5-HYDROXYMETHYLTHIAZOLE 687636-93-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

687636-93-7, 2-BROMO-5-HYDROXYMETHYLTHIAZOLERelated Search:

2-BROMO-5-(METHYLSULFONYL)PYRIDINE 2-BROMO-5-CHLOROBENZONITRILE 2-BROMO-5-HYDROXYMETHYLTHIAZOLE 2-Bromo-4-thiazolecarboxylic acid ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 2-bromothiazole-5-carboxylate 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Methyl 2-bromothiazole-5-carboxylate 2-Bromothiazole 5-Hydroxymethylthiazole 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 2,4-Dibromothiazole-5-methanol 5-Thiazolecarboxylic acid, 2,4-dibromo- 5-Thiazolecarboxylicacid,2-bromo-4-(1,1-dimethylethyl)-,ethylester(9CI) 5-Thiazolecarboxylicacid,2-bromo-4-methyl-,methylester(9CI) 2-Bromo-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid 2-BROMO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER RARECHEM AL BP 1435

2-Bromo-5-hydromethylthiazole

(2-Bromo-1,3-thiazol-5-yl)methanol 97%

2-Bromo-5-(hydroxymethyl)-1,3-thiazole

(2-bromo-5-thiazolyl)methanol

(2-bromothiazol-5-yl)methanol

2-Bromo-5-(hydroxymethyl)-1,3-thiazole 97%

RARECHEM AL BD 1435

(2-BROMO-1,3-THIAZOL-5-YL)METHANOL

2-BROMO-5-HYDROXYMETHYLTHIAZOLE

2-BROMOTHIAZOLE-5-METHANOL

2-Bromo-5-(hydroxymethyl)-1,3-thiazole97%

2-Bromo-5-thiazolemethanol

5-Thiazolemethanol, 2-bromo-

CAS:687636-93-7

687636-93-7

blocks

Bromides

Thiazoles

Building Blocks

Thiazole