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2-BROMO-5-HYDROXYMETHYLTHIAZOLE

Product Name
2-BROMO-5-HYDROXYMETHYLTHIAZOLE
CAS No.
687636-93-7
Chemical Name
2-BROMO-5-HYDROXYMETHYLTHIAZOLE
Synonyms
CAS:687636-93-7;RARECHEM AL BD 1435;2-BROMOTHIAZOLE-5-METHANOL;2-Bromo-5-thiazolemethanol;5-Thiazolemethanol, 2-bromo-;2-Bromo-5-hydromethylthiazole;(2-bromothiazol-5-yl)methanol;(2-bromo-5-thiazolyl)methanol;2-BROMO-5-HYDROXYMETHYLTHIAZOLE;(2-BROMO-1,3-THIAZOL-5-YL)METHANOL
CBNumber
CB8669339
Molecular Formula
C4H4BrNOS
Formula Weight
194.05
MOL File
687636-93-7.mol
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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Property

Melting point:
46-48
Boiling point:
288.3±15.0 °C(Predicted)
Density 
1.899±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder
pka
13.23±0.10(Predicted)
color 
Light yellow
CAS DataBase Reference
687636-93-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
Hazard Note 
Irritant
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00336
Product name
2-Bromo-5-hydroxymethylthiazole
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
B688388
Product name
2-Bromothiazole-5-methanol
Packaging
250mg
Price
$55
Updated
2021/12/16
Ark Pharm
Product number
P000175268
Product name
2-Bromothiazole-5-methanol
Purity
97%
Packaging
250mg
Price
$24
Updated
2021/12/16
Oakwood
Product number
079893
Product name
2-Bromothiazole-5-methanol
Purity
98%
Packaging
1g
Price
$50
Updated
2021/12/16
Ark Pharm
Product number
P000175268
Product name
2-Bromothiazole-5-methanol
Purity
97%
Packaging
1g
Price
$50
Updated
2021/12/16
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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production

Synthesis

464192-28-7

687636-93-7

General procedure for the synthesis of 2-bromothiazole-5-methanol from 2-bromo-5-formylthiazole: 2-bromothiazole-5-formaldehyde (3.00 g, 15.62 mmol) was mixed with methanol (50 mL). The mixture was cooled to 0 °C under nitrogen protection and sodium borohydride (0.591 g, 15.62 mmol) was added in batches. The reaction was stirred at this temperature for 2 hours. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. To the residue, saturated aqueous ammonium chloride solution was added, and the pH was adjusted to about 6 with 1 M aqueous hydrochloric acid, and then adjusted to about 10 with 1 M aqueous sodium hydroxide. the mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with saturated brine, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography eluting with a gradient of ethyl acetate/hexane (10% to 25%) to give 2-bromothiazole-5-methanol as a light yellow oil. Mass spectrum (DCI+) m/z 194,196 (M+H)+.

References

[1] Patent: WO2012/87833, 2012, A1. Location in patent: Page/Page column 125-126
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6303 - 6306
[3] Patent: WO2004/37818, 2004, A1. Location in patent: Page 69 - 70
[4] Patent: WO2007/75749, 2007, A2. Location in patent: Page/Page column 25; 37-39
[5] Patent: WO2009/77990, 2009, A1. Location in patent: Page/Page column 92

2-BROMO-5-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-HYDROXYMETHYLTHIAZOLE Suppliers

China 108 Germany 2 India 2 United Kingdom 3 United States 20 Global 135
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-BROMO-5-HYDROXYMETHYLTHIAZOLE manufacturers

Career Henan Chemical Co
Product
2-BROMO-5-HYDROXYMETHYLTHIAZOLE 687636-93-7
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-08

687636-93-7, 2-BROMO-5-HYDROXYMETHYLTHIAZOLERelated Search:

2-BROMO-5-(METHYLSULFONYL)PYRIDINE 2-BROMO-5-CHLOROBENZONITRILE 2-BROMO-5-HYDROXYMETHYLTHIAZOLE 2-Bromo-4-thiazolecarboxylic acid ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 2-bromothiazole-5-carboxylate 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Methyl 2-bromothiazole-5-carboxylate 2-Bromothiazole 5-Hydroxymethylthiazole 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 2,4-Dibromothiazole-5-methanol 5-Thiazolecarboxylic acid, 2,4-dibromo- 5-Thiazolecarboxylicacid,2-bromo-4-(1,1-dimethylethyl)-,ethylester(9CI) 5-Thiazolecarboxylicacid,2-bromo-4-methyl-,methylester(9CI) 2-Bromo-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid 2-BROMO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER RARECHEM AL BP 1435

  • 2-Bromo-5-hydromethylthiazole
  • (2-Bromo-1,3-thiazol-5-yl)methanol 97%
  • 2-Bromo-5-(hydroxymethyl)-1,3-thiazole
  • (2-bromo-5-thiazolyl)methanol
  • (2-bromothiazol-5-yl)methanol
  • 2-Bromo-5-(hydroxymethyl)-1,3-thiazole 97%
  • RARECHEM AL BD 1435
  • (2-BROMO-1,3-THIAZOL-5-YL)METHANOL
  • 2-BROMO-5-HYDROXYMETHYLTHIAZOLE
  • 2-BROMOTHIAZOLE-5-METHANOL
  • 2-Bromo-5-(hydroxymethyl)-1,3-thiazole97%
  • 2-Bromo-5-thiazolemethanol
  • 5-Thiazolemethanol, 2-bromo-
  • CAS:687636-93-7
  • 687636-93-7
  • blocks
  • Bromides
  • Thiazoles
  • Building Blocks
  • Thiazole