5-Hydroxymethylthiazole
- Product Name
- 5-Hydroxymethylthiazole
- CAS No.
- 38585-74-9
- Chemical Name
- 5-Hydroxymethylthiazole
- Synonyms
- THIAZOLE-5-METHANOL;5-ylmethanol;5-Hydroxythiazole;CHEMBRDG-BB 4050354;5-THIAZOLE METHANOL;RARECHEM AL BD 1261;5-thiazolylmethanol;THIAZOL-5-YL-METHANOL;Ritonavir Impurity 17;-HydroxyMethylthiazole
- CBNumber
- CB8119430
- Molecular Formula
- C4H5NOS
- Formula Weight
- 115.15
- MOL File
- 38585-74-9.mol
5-Hydroxymethylthiazole Property
- Boiling point:
- 95-96°C 0,02mm
- Density
- 1.32
- vapor pressure
- 1.9Pa at 25℃
- refractive index
- 1.5670 to 1.5710
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform, Methanol
- form
- Oil
- pka
- 13.61±0.10(Predicted)
- color
- Pale-Yellow
- LogP
- -0.17 at 22℃
- Surface tension
- 57.8mN/m at 1.1g/L and 20℃
- CAS DataBase Reference
- 38585-74-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-52/53-41-40
- Safety Statements
- 26-36/37/39-61-39-36-22
- Hazard Note
- Irritant
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T2779
- Product name
- 5-Thiazolemethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- T2779
- Product name
- 5-Thiazolemethanol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $197
- Updated
- 2025/07/31
- Product number
- T344200
- Product name
- 5-Thiazolemethanol
- Packaging
- 500mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- CHM0027205
- Product name
- 5-HYDROXYMETHYLTHIAZOLE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1732.5
- Updated
- 2021/12/16
- Product number
- 13788
- Product name
- 5-Thiazolemethanol
- Packaging
- 250mg
- Price
- $2000
- Updated
- 2021/12/16
5-Hydroxymethylthiazole Chemical Properties,Usage,Production
Chemical Properties
Pale-Yellow Oil
Uses
5-Thiazolemethanol (cas# 38585-74-9) is a compound useful in organic synthesis.
Synthesis
32955-22-9
38585-74-9
The general procedure for the synthesis of 5-hydroxymethylthiazole from ethyl thiazole-5-carboxylate was as follows: a 250 mL THF solution of lithium aluminum hydride (2.89 g, 76 mmol) was added to a pre-cooled (ice-bath) 500 mL three-neck flask. Subsequently, ethyl thiazole-5-carboxylate (11.82 g, 75.68 mmol) was dissolved in 100 mL of THF and slowly added dropwise to the reaction system over a period of 1.5 h to avoid violent foaming. After the dropwise addition was completed, stirring of the reaction mixture was continued for 1 hour. Upon completion of the reaction, 2.9 mL of water, 2.9 mL of 15% NaOH solution, and 8.7 mL of water were carefully added sequentially to quench the reaction. The solid salt was removed by filtration and the filtrate was retained. The crude product salt was heated at reflux in 100 mL of ethyl acetate for 30 minutes and then filtered. The filtrates from the two filtrations were combined, dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The product was purified by silica gel column chromatography using sequentially 0%, 2%, and 4% chloroform solution of methanol as eluent, and fractions with an Rf value of 0.3 (chloroform solution of 4% methanol) were collected and left to solidify to give the target compound in 75% yield. The structure of the product was confirmed by NMR (CDCl3) δ 4.92 (s, 2H), 7.78 (s, 1H), 8.77 (s, 1H) and mass spectra ((M + H)+ = 116).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 3124 - 3153
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 602 - 617
[3] Patent: US5914332, 1999, A
[4] Patent: US5455351, 1995, A
[5] Patent: US5559158, 1996, A
5-Hydroxymethylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Hydroxymethylthiazole manufacturers
- Product
- 5-Hydroxymethylthiazole 38585-74-9
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- 5-Hydroxymethylthiazole 38585-74-9
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06
- Product
- 5-Hydroxymethylthiazole 38585-74-9
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06