ChemicalBook > CAS DataBase List > 2-BROMO-5-CHLOROBENZONITRILE

2-BROMO-5-CHLOROBENZONITRILE

Product Name
2-BROMO-5-CHLOROBENZONITRILE
CAS No.
57381-37-0
Chemical Name
2-BROMO-5-CHLOROBENZONITRILE
Synonyms
2-Bromo-5-chlorobenzonitile;2-BROMO-5-CHLOROBENZONITRILE;Benzonitrile, 2-bromo-5-chloro-
CBNumber
CB3486700
Molecular Formula
C7H3BrClN
Formula Weight
216.46
MOL File
57381-37-0.mol
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2-BROMO-5-CHLOROBENZONITRILE Property

Melting point:
138.8-139.2°C
Boiling point:
271.6±25.0 °C(Predicted)
Density 
1.74±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder
color 
Yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B683663
Product name
2-Bromo-5-chlorobenzonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
OR6705
Product name
2-Bromo-5-chlorobenzonitrile
Packaging
5g
Price
$21
Updated
2021/12/16
Matrix Scientific
Product number
056908
Product name
2-Bromo-5-chlorobenzonitrile
Purity
98%
Packaging
5g
Price
$24
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-D-X3
Product name
2-Bromo-5-chlorobenzonitrile
Packaging
5G
Price
$29
Updated
2021/12/16
Apolloscientific
Product number
OR6705
Product name
2-Bromo-5-chlorobenzonitrile
Packaging
25g
Price
$67
Updated
2021/12/16
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2-BROMO-5-CHLOROBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

766-84-7

57381-37-0

The general procedure for the synthesis of 2-bromo-5-chlorobenzonitrile using 3-chlorobenzonitrile as starting material was as follows: sulfuric acid (24 mL) was slowly added to a solution of 3-chlorobenzonitrile (50 g, 360 mmol) in trifluoroacetic acid (180 mL), followed by the addition of 1,3-dibromo-5,5-dimethyl-acetonitriles (67 g, 234 mmol) in batches over an 8-min period. During the reaction, the temperature was raised to 31 °C and then controlled at 24 °C by cooling. After 6 h of reaction, the non-homogeneous reaction mixture was cooled to 10 °C and quenched by the addition of water (250 mL).After 10 min, the reaction mixture was filtered and the filter cake was washed twice sequentially with water (250 mL and 100 mL) to give the final white solid product 2-bromo-5-chlorobenzonitrile (52.4 g, 63% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz) δ 7.64-7.62 (m, 2H), 7.44 (dd, J = 8.6, 2.5 Hz, 1H) and 13C NMR (CDCl3, 100 MHz) δ 134.2, 134.1, 133.9, 133.8, 123.3, 117.2, 115.8.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 9, p. 3026 - 3035
[2] Tetrahedron, 2004, vol. 60, # 50, p. 11367 - 11374
[3] Organic Letters, 2006, vol. 8, # 18, p. 3903 - 3906
[4] Patent: US2004/181070, 2004, A1. Location in patent: Page 11
[5] Patent: US2004/181070, 2004, A1. Location in patent: Page 11

2-BROMO-5-CHLOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-CHLOROBENZONITRILE Suppliers

China 110 Germany 1 India 3 United Kingdom 4 United States 12 Global 130
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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sales@chemwish.com
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China
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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sales@sinch.com.cn
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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China
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Adamas Reagent, Ltd.
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Shanghai Harvest Chemical Industrial Co., Ltd.
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sales@harvest-chem.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Shandong Xiya Chemical Co., Ltd
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4009903999 13355009207
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0539-6365991
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3007715519@qq.com
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China
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18729
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View Lastest Price from 2-BROMO-5-CHLOROBENZONITRILE manufacturers

Honest Joy Holdings Limited
Product
2-Bromo-5-chlorobenzonitrile 57381-37-0
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
2-Bromo-5-chlorobenzonitrile 57381-37-0
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09
Career Henan Chemical Co
Product
2-BROMO-5-CHLOROBENZONITRILE 57381-37-0
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

57381-37-0, 2-BROMO-5-CHLOROBENZONITRILERelated Search:

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  • 2-BROMO-5-CHLOROBENZONITRILE
  • 2-Bromo-5-chlorobenzonitile
  • Benzonitrile, 2-bromo-5-chloro-
  • 57381-37-0