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2-BROMO-4-CHLOROBENZONITRILE

Product Name
2-BROMO-4-CHLOROBENZONITRILE
CAS No.
57381-49-4
Chemical Name
2-BROMO-4-CHLOROBENZONITRILE
Synonyms
2-BROMO-4-CHLOROBENZONITRILE;Benzonitrile, 2-bromo-4-chloro-;2-bromo-4-chlorophenyl-carbonitrile
CBNumber
CB9849767
Molecular Formula
C7H3BrClN
Formula Weight
216.46
MOL File
57381-49-4.mol
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2-BROMO-4-CHLOROBENZONITRILE Property

Melting point:
73-75°
Boiling point:
284.0±25.0℃ (760 Torr)
Density 
1.74±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:
125.6±23.2℃
storage temp. 
Sealed in dry,Room Temperature
form 
solid
color 
Cream
InChI
InChI=1S/C7H3BrClN/c8-7-3-6(9)2-1-5(7)4-10/h1-3H
InChIKey
PEAQTMSQUXACRN-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(Cl)C=C1Br
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Safety

HazardClass 
IRRITANT
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B683658
Product name
2-Bromo-4-chlorobenzonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
B683658
Product name
2-Bromo-4-chlorobenzonitrile
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
056907
Product name
2-Bromo-4-chlorobenzonitrile
Purity
98%
Packaging
1g
Price
$22
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-D-X7
Product name
2-Bromo-4-chlorobenzonitrile
Packaging
250mg
Price
$35
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-D-X7
Product name
2-Bromo-4-chlorobenzonitrile
Packaging
1g
Price
$45
Updated
2021/12/16
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2-BROMO-4-CHLOROBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

936-08-3

57381-49-4

Example 1A Synthesis of 2-bromo-4-chlorobenzonitrile: 588 mg (2.5 mmol) of 2-bromo-4-chlorobenzoic acid was dissolved with 300 mg of urea in a mixed solvent of dichloromethane/methanol, and subsequently concentrated over 364 mg of neutral alumina by rotary evaporator. The resulting mixture was microwaved at 150 °C for 60 min. After completion of the reaction, the reaction mixture was cooled and the residue was stirred with ethyl acetate and water, followed by filtration and separation of the aqueous phase. The organic phase was washed with sodium bicarbonate solution, dried over anhydrous sodium sulfate, then concentrated by rotary evaporator and finally dried under high vacuum. The crude product 383 mg (80% purity, 57% yield) was obtained, which could be used for subsequent reactions without further purification.1H NMR (300 MHz, CDCl3) δ: 7.72 (d, 1H), 7.60 (d, 1H), 7.42 (dd, 1H).

References

[1] Patent: US2009/181996, 2009, A1. Location in patent: Page/Page column 9-10
[2] Patent: WO2006/8046, 2006, A1. Location in patent: Page/Page column 47-48
[3] Patent: US2008/261964, 2008, A1. Location in patent: Page/Page column 9

2-BROMO-4-CHLOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-CHLOROBENZONITRILE Suppliers

China 78 India 4 Switzerland 1 United Kingdom 3 United States 9 Global 95
Shanghai ACT chemical Limited
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jkinfo@jkchemical.com
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Energy Chemical
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57381-49-4, 2-BROMO-4-CHLOROBENZONITRILERelated Search:

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  • 57381-49-4