ChemicalBook > CAS DataBase List > 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- Product Name
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- CAS No.
- 5198-86-7
- Chemical Name
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE
- Synonyms
- 2-BROMOTHIAZOLE-4-METHANOL;2-Bromo-4-thiazolemethanol;2-Bromo-4-thiazolylmethanol;4-ThiazoleMethanol,2-broMo-;(2-bromothiazol-4-yl)methanol;2-BROMO-4-HYDROXYMETHYLTHIAZOLE;(2-bromo-1,3-thiazol-4-yl)methanol;(2-BROMO-1,3-THIAZOLE-4-YL)METHANOL;2-Bromo-4-(hydroxymethyl)-1,3-thiazole;2-Bromo-4-(hydroxymethyl)-1,3-thiazole97%
- CBNumber
- CB5463116
- Molecular Formula
- C4H4BrNOS
- Formula Weight
- 194.05
- MOL File
- 5198-86-7.mol
More
Less
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Property
- Boiling point:
- 56 °C(Press: 10 Torr)
- Density
- 1.899±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- liquid
- pka
- 12.82±0.10(Predicted)
- color
- Light yellow
- CAS DataBase Reference
- 5198-86-7(CAS DataBase Reference)
More
Less
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00394
- Product name
- 2-Bromo-4-hydroxymethylthiazole
- Packaging
- 1g
- Price
- $356
- Updated
- 2025/07/31
TRC
- Product number
- B688383
- Product name
- 2-Bromothiazole-4-methanol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- B688383
- Product name
- 2-Bromothiazole-4-methanol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 8H01-9-X0
- Product name
- 2-Bromo-4-(hydroxymethyl)-1,3-thiazole
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 069441
- Product name
- 2-Bromo-4-hydroxymethylthiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $331
- Updated
- 2021/12/16
More
Less
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Chemical Properties,Usage,Production
Synthesis
100367-77-9
5198-86-7
General procedure for the synthesis of 2-bromothiazole-4-methanol from ethyl 2-bromothiazole-4-carboxylate: In a dry reaction flask, ethyl 2-bromothiazole-4-carboxylate (10.0 g, 42.4 mmol, 1 eq.) was dissolved in tetrahydrofuran (200 mL), and sodium borohydride (4.81 g, 127 mmol, 3 eq.), lithium chloride (5.4 g, 130 mmol, 3 eq.), and water (40 mL) were added in sequence. 130 mmol, 3 equiv) and water (40 mL). The resulting two-phase mixture was stirred vigorously at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 20% ethyl acetate/hexane) to confirm complete consumption of the raw materials. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (200 mL), diluted with the addition of ethyl acetate (200 mL), and the organic and aqueous layers were separated. The aqueous layer was extracted with ethyl acetate (100 mL), the organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-bromothiazole-4-methanol as a yellow semi-solid (7.82 g, 95% yield). The Rf value of the thin-layer chromatography was 0.2 (silica gel plate, unfolding agent was 20% ethyl acetate/hexane); the 1H NMR and 13C NMR spectra of the product were consistent with those reported in the literature (Wipf and Wang, 2007).
References
[1] Patent: WO2015/57585, 2015, A1. Location in patent: Page/Page column 27; 28
[2] Patent: CN104478866, 2017, B. Location in patent: Paragraph 0281; 0283; 0284
[3] Patent: CN104478869, 2017, B. Location in patent: Paragraph 0142; 0143; 0144; 0145
[4] Patent: WO2017/184624, 2017, A1. Location in patent: Page/Page column 185; 186
[5] Journal of Organic Chemistry, 2016, vol. 81, # 21, p. 10302 - 10320
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-BROMO-4-HYDROXYMETHYLTHIAZOLE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 18049974220
- Fax
- +86 (21) 51062076
- 3060526242@qq.com
- Country
- China
- ProdList
- 995
- Advantage
- 60
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 021-54849683 13601642561
- Fax
- +86-21-54375689
- sales@keepontech.com
- Country
- China
- ProdList
- 998
- Advantage
- 59
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-15861285899
- Fax
- +86-518-86661625
- sales@rebobiochem.com
- Country
- China
- ProdList
- 100
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 02161555100
- Fax
- -
- Country
- China
- ProdList
- 820
- Advantage
- 58
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 515-88280676 18921872653
- sales@ximanbio.com
- Country
- China
- ProdList
- 1524
- Advantage
- 56
- Tel
- 027-67849912
- Fax
- 027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 9148
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-34053660
- Fax
- QQ:2881074831
- sale2@labgogo.com
- Country
- China
- ProdList
- 2018
- Advantage
- 58
- Tel
- 18621295758
- Fax
- -QQ:1449085402
- 1449085402@qq.com
- Country
- China
- ProdList
- 1724
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9713
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 15722927296
- Fax
- -
- 71139532@qq.com
- Country
- China
- ProdList
- 426
- Advantage
- 58
- Tel
- 19951936396
- 1815156226@qq.com
- Country
- China
- ProdList
- 2947
- Advantage
- 58
- Tel
- 025-87138562
- sales@popebiotech.com
- Country
- China
- ProdList
- 413
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- +86-188369842 +86-15618151133
- Fax
- QQ188369842
- 188369842@qq.com
- Country
- China
- ProdList
- 1959
- Advantage
- 58
- Tel
- 027-69573188 18221423799
- 1503407886@qq.com
- Country
- China
- ProdList
- 1439
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10237
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
More
Less
View Lastest Price from 2-BROMO-4-HYDROXYMETHYLTHIAZOLE manufacturers
Career Henan Chemical Co
- Product
- 2-BROMO-4-HYDROXYMETHYLTHIAZOLE 5198-86-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02
5198-86-7, 2-BROMO-4-HYDROXYMETHYLTHIAZOLERelated Search:
(2-METHYL-1,3-THIAZOL-4-YL)METHANOL
2-Chloro-4-thiazole-Methanol
2-Bromo-4-thiazolecarboxylic acid
2-BROMO-4-HYDROXYMETHYLTHIAZOLE
Ethyl 2-bromothiazole-4-carboxylate
2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE
2-Bromothiazole
4-Hydroxymethylthiazole
2,4-Dibromothiazole-5-methanol
2-BROMO-5-HYDROXYMETHYLTHIAZOLE
2,5-DIBROMO-4-(HYDROXYMETHYL)THIAZOLE
Methyl 2-bromo-5-isopropyl-1,3-thiazole-4-carboxylate
ETHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE
2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID
2,5-DIBROMOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER
2-BROMO-5-ISOPROPYLTHIAZOLE-4-CARBOXYLATE
METHYL 2-BROMO-5-CHLOROTHIAZOLE-4-CARBOXYLATE