2-(2-Aminothiazol-4-yl)glyoxylic acid
- Product Name
- 2-(2-Aminothiazol-4-yl)glyoxylic acid
- CAS No.
- 73150-67-1
- Chemical Name
- 2-(2-Aminothiazol-4-yl)glyoxylic acid
- Synonyms
- ATGA;2-(2-AMinothiazol-4-yl)Glyoxy;2-Amino-4-thiazoleglyoxylic Acid;2-amino-α-oxothiazol-4-acetic acid;2-Amino-α-oxo-4-thiazoleacetic acid;4-Thiazoleacetic acid, 2-amino-α-oxo-;2-amino-alpha-oxothiazol-4-acetic acid;2-(2-AMINOTHIAZOL-4-YL) GLYOXYLIC ACID;2-(2-Amino-4-thiazolyl)-2-oxoacetic Acid;2-(2-AMINOTHIAZOL-4-YL)-2-OXO-ACETIC ACID
- CBNumber
- CB8170233
- Molecular Formula
- C5H4N2O3S
- Formula Weight
- 172.16
- MOL File
- 73150-67-1.mol
2-(2-Aminothiazol-4-yl)glyoxylic acid Property
- Boiling point:
- 395.7±24.0 °C(Predicted)
- Density
- 1.711±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO
- pka
- 1.25±0.54(Predicted)
- form
- Solid
- color
- Pale Yellow
- InChI
- InChI=1S/C5H4N2O3S/c6-5-7-2(1-11-5)3(8)4(9)10/h1H,(H2,6,7)(H,9,10)
- InChIKey
- VMASTYPGLHRVNL-UHFFFAOYSA-N
- SMILES
- C1(C(=O)C(=O)O)N=C(N)SC=1
- CAS DataBase Reference
- 73150-67-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A630205
- Product name
- 2-Amino-4-thiazoleglyoxylicAcid
- Packaging
- 5g
- Price
- $595
- Updated
- 2021/12/16
- Product number
- FA29941
- Product name
- 2-(2-Aminothiazol-4-yl) glyoxylic acid
- Packaging
- 5G
- Price
- $700
- Updated
- 2021/12/16
- Product number
- K980
- Product name
- 2-(2-Aminothiazol-4-yl)glyoxylicacid
- Packaging
- 10g
- Price
- $725
- Updated
- 2021/12/16
- Product number
- FA29941
- Product name
- 2-(2-Aminothiazol-4-yl) glyoxylic acid
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- K980
- Product name
- 2-(2-Aminothiazol-4-yl)glyoxylicacid
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
2-(2-Aminothiazol-4-yl)glyoxylic acid Chemical Properties,Usage,Production
Uses
2-Amino-4-thiazoleglyoxylic Acid is an intermediate in synthesizing (6R,7R)-7-(2-(2-Aminothiazol-4-yl)-2-oxoacetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (A630310), which is used in the preparation of Cephalosporin C (C258750), an antibiotic used to study the effect of transpeptidase expression, binding, and inhibition on bacterial cell wall mucopeptide synthesis.
Synthesis
89721-50-6
73150-67-1
Under ice bath cooling conditions, 10.1 g of methyl 2-(2-aminothiazol-4-yl)thioacetoxy S-acid (CAS: 89721-50-6) was mixed with 80 mL of water, followed by the addition of 10.6 g of sodium carbonate. The reaction mixture was stirred continuously for 1 h at a maintained ice bath temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 2.5 at the same temperature using 6 N hydrochloric acid. the precipitated crystals were collected by filtration, washed with deionized water and subsequently dried to afford 6.2 g (67.8% yield) of 2-(2-aminothiazol-4-yl)glyoxalic acid with a melting point of more than 200°C. The infrared spectra of the product (KBr pressed slice) showed a νC=O absorption peak at 1660 cm?1.
References
[1] Patent: US4563534, 1986, A
2-(2-Aminothiazol-4-yl)glyoxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2-Aminothiazol-4-yl)glyoxylic acid manufacturers
- Product
- 2-(2-Aminothiazol-4-yl)glyoxylic acid 73150-67-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08