2,4-Dibromothiazole
- Product Name
- 2,4-Dibromothiazole
- CAS No.
- 4175-77-3
- Chemical Name
- 2,4-Dibromothiazole
- Synonyms
- 2,4-Dibromo-1,3-thiazole;2,4-BROMOTHIAZOLE;2,4-Dibrmothiazole;2,4-dibormothiazole;2,4-DIBROMOTHIAZOLE;2,4-Dibromothiazole>Thiazole, 2,4-dibroMo-;2,4-DIBROMOTHIAZOLE 98%;2,4-Dibromothiazole ,98%;2,4-DIBROMOTHIAZOLE, 97+%
- CBNumber
- CB0179775
- Molecular Formula
- C3HBr2NS
- Formula Weight
- 242.92
- MOL File
- 4175-77-3.mol
2,4-Dibromothiazole Property
- Melting point:
- 80-84 °C
- Boiling point:
- 242.8±13.0 °C(Predicted)
- Density
- 2.324±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -1.93±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C3HBr2NS/c4-2-1-7-3(5)6-2/h1H
- InChIKey
- MKEJZKKVVUZXIS-UHFFFAOYSA-N
- SMILES
- S1C=C(Br)N=C1Br
- CAS DataBase Reference
- 4175-77-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-39-36-37/39
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 677914
- Product name
- 2,4-Dibromothiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $27.79
- Updated
- 2025/07/31
- Product number
- 677914
- Product name
- 2,4-Dibromothiazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- D3667
- Product name
- 2,4-Dibromothiazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- D3667
- Product name
- 2,4-Dibromothiazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D3667
- Product name
- 2,4-Dibromothiazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $161
- Updated
- 2025/07/31
2,4-Dibromothiazole Chemical Properties,Usage,Production
Chemical Properties
Off-white crystalline powder
Uses
2,4-Dibromothiazole is an intermediate used in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modula tors.
Uses
2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.
Uses
Building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain.
Synthesis
2295-31-0
4175-77-3
General procedure for the synthesis of 2,4-dibromothiazoles from 2,4-thiazolidinediones: Example 41: Preparation of 2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-(1,3-thiazol-4-yl)-3,5-dihydro-4H-imidazol-4-one Step a) Preparation of compound 2 A mixture of 2,4-thiazolidinedione 1 (2.28 g, 19.5 mmol) with phosphorus tribromide (25.0 g, 87.0 mmol) was heated at 130°C for 30 min and subsequently cooled to room temperature. The reaction mixture was diluted with ice water (300 mL) and neutralized by batchwise addition of solid sodium carbonate. After neutralization was complete, the mixture was extracted with dichloromethane (3 x 150 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (silica gel, elution gradient: 0:100 to 5:95 ethyl acetate/hexane) to afford compound 2 (3.34 g, 71%) as light yellow crystals.1H NMR (500 MHz, CDCl3) δ 7.21 (s, 1H).
References
[1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3754 - 3761
[2] Synthesis, 2012, vol. 44, # 7, p. 1026 - 1029
[3] Journal of Materials Chemistry C, 2017, vol. 5, # 45, p. 11927 - 11936
[4] Patent: US2007/4786, 2007, A1. Location in patent: Page/Page column 21
[5] Tetrahedron, 2006, vol. 62, # 38, p. 9017 - 9037
2,4-Dibromothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dibromothiazole manufacturers
- Product
- 2,4-Dibromothiazole 4175-77-3
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2,4-Dibromothiazole 4175-77-3
- Price
- US $67.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100000
- Release date
- 2024-08-16
- Product
- 2,4-Dibromothiazole 4175-77-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31