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MMP-8 INHIBITOR I

Product Name
MMP-8 INHIBITOR I
CAS No.
236403-25-1
Chemical Name
MMP-8 INHIBITOR I
Synonyms
MMP 8-I;MMP-8 INHIBITOR I;MMP-8 Inhibitor I (Matrix Metalloproteinase-8 Inhibitor I);(3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE];3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-
CBNumber
CB4710190
Molecular Formula
C17H18N2O5S
Formula Weight
362.4
MOL File
Mol file
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MMP-8 INHIBITOR I Property

storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Light Yellow
InChI
InChI=1S/C17H18N2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m1/s1
InChIKey
PPELJLBDXLMTEW-MRXNPFEDSA-N
SMILES
C1C2=C(C=CC=C2)C[C@H](C(NO)=O)N1S(C1=CC=C(OC)C=C1)(=O)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21852
Product name
MMP-8 Inhibitor I
Purity
≥95%
Packaging
1mg
Price
$201
Updated
2024/03/01
TRC
Product number
M425440
Product name
MMP8-I
Packaging
100mg
Price
$1135
Updated
2021/12/16
AK Scientific
Product number
9999CR
Product name
Mmp-8inhibitori
Packaging
1mg
Price
$322
Updated
2021/12/16
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MMP-8 INHIBITOR I Chemical Properties,Usage,Production

Description

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.

Uses

MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells.

in vivo

MMP-8 inhibitor-1 (compound 21) (100 mg/kg, orally) has not significant oral bioavailability, with maximal plasma levels (Cmax) of only 2.3 mg/mL[1].

IC 50

MMP-8

References

[1] HANS MATTER. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure–activity relationship[J]. Bioorganic & Medicinal Chemistry, 2002, 10 11: Pages 3529-3544. DOI: 10.1016/s0968-0896(02)00215-8
[2] MCNULTY A, WEINBERG B J, GUILAK F. Inhibition of Matrix Metalloproteinases Enhances In Vitro Repair of the Meniscus[C]//38 1. 2009: 0. DOI: 10.1007/s11999-008-0596-6
[3] GERALD W PRAGER. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.[J]. Blood, 2004, 103 3: 955-962. DOI: 10.1182/blood-2003-07-2214
[4] QISHAN CHEN. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.[J]. Mediators of Inflammation, 2013: 928315. DOI: 10.1155/2013/928315
[5] JULIE DECOCK. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.[J]. Breast Cancer Research?: BCR, 2015: 38. DOI: 10.1186/s13058-015-0545-8
[6] MUGE SARPER. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.[J]. Breast Cancer Research?: BCR, 2017: 33. DOI: 10.1186/s13058-017-0822-9

MMP-8 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-8 INHIBITOR I Suppliers

China 14 Japan 1 United Kingdom 1 United States 4 Global 20
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
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60
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
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58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58

236403-25-1, MMP-8 INHIBITOR IRelated Search:


  • (3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE]
  • MMP-8 INHIBITOR I
  • MMP 8-I
  • 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-
  • MMP-8 Inhibitor I (Matrix Metalloproteinase-8 Inhibitor I)
  • 236403-25-1