ChemicalBook > CAS DataBase List > H-HOMOPRO-OME HCL

H-HOMOPRO-OME HCL

Product Name
H-HOMOPRO-OME HCL
CAS No.
18650-39-0
Chemical Name
H-HOMOPRO-OME HCL
Synonyms
L-PIP-OME;H-HOPRO-OME HCL;H-PIC(2)-OME HCL;L-HOMOPRO-OME-HCL;H-HOMOPRO-OME HCL;HOMOPROLINE-OME HCL;L-PIPECOLIC ACID-OME HCL;Homoproline-OMe Hydrochloride;L-HOMO-PROLINE METHYL ESTER HCL;METHYL L-PIPECOLATE HYDROCHLORIDE
CBNumber
CB4711960
Molecular Formula
C7H14ClNO2
Formula Weight
179.64
MOL File
18650-39-0.mol
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H-HOMOPRO-OME HCL Property

Melting point:
176-177℃
storage temp. 
Inert atmosphere,2-8°C
form 
powder
color 
White to off-white
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M356753
Product name
Methyl(2S)-Piperidine-2-carboxylateHydrochloride
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
068950
Product name
Methyl (2S)-piperidine-2-carboxylate hydrochloride
Purity
>95%
Packaging
5g
Price
$74
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-5-S1
Product name
Methyl (2S)-piperidinecarboxylate hydrochloride
Purity
97%
Packaging
250mg
Price
$125
Updated
2021/12/16
Activate Scientific
Product number
AS13397-B
Product name
(S)-Piperidine-2-carboxylic acid methyl ester HCl
Purity
96+% ee
Packaging
1g
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
068950
Product name
Methyl (2S)-piperidine-2-carboxylate hydrochloride
Purity
>95%
Packaging
1g
Price
$24
Updated
2021/12/16
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H-HOMOPRO-OME HCL Chemical Properties,Usage,Production

Uses

Methyl (2S)-Piperidine-2-carboxylate Hydrochloride can be useful in the preparation of Thyrotropin-?releasing hormone (TRH) analogs, preparation of (arylsulfonyl)(amidino)phenylalanine piperidinamides as matriptase inhibitors, stereoselective synthesis of protected peptides containing anti β-hydroxy tyrosine, preparation of analogs of endogenous neuropeptide cycloprolylglycine, and preparation of promysalin analogs. It can also be useful in the preparation of molecular switches within ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford mGlu5 modulators.

Synthesis

67-56-1

3105-95-1

18650-39-0

Under argon protection, (S)-piperidine-2-carboxylic acid (10.00 g, 77.46 mmol) was dissolved in methanol (200 ml) and cooled to 0°C. Subsequently, thionyl chloride (15.0 ml, 205.61 mmol) was slowly added. The reaction mixture was stirred at 0 °C for 30 min and then heated to reflux overnight. After completion of the reaction, the solvent was removed by evaporation and the residue was recrystallized from ethanol to afford methyl (S)-piperidine-2-carboxylate hydrochloride (9.90 g, 92% yield). Mass spectrometry (EIMS) showed m/z 144.1 ([M+H]+).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 23, p. 7333 - 7342
[2] Chemistry - A European Journal, 2010, vol. 16, # 25, p. 7547 - 7553
[3] Patent: WO2015/28850, 2015, A1. Location in patent: Page/Page column 88
[4] Tetrahedron Letters, 1991, vol. 32, # 49, p. 7183 - 7186
[5] Patent: WO2014/19344, 2014, A1. Location in patent: Paragraph 00601

H-HOMOPRO-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-HOMOPRO-OME HCL manufacturers

Career Henan Chemical Co
Product
H-HOMOPRO-OME HCL 18650-39-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-10

18650-39-0, H-HOMOPRO-OME HCLRelated Search:

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