METHYL PIPECOLINATE HYDROCHLORIDE
- Product Name
- METHYL PIPECOLINATE HYDROCHLORIDE
- CAS No.
- 32559-18-5
- Chemical Name
- METHYL PIPECOLINATE HYDROCHLORIDE
- Synonyms
- METHYL PIPERIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-DL-Pip-OMe·HCl;TIMTEC-BB SBB003755;METHY PIPECOLINATE HCL;METHYL PIPECOLINATE HCL;MethyPipecolinateHydrochloride;METHYL PIPECOLINATE HYDROCHLORIDE;N-methyl pipecolinate hydrochloride;Methyl piperidine-2-carboxylate HCl;pipecolinic acid methyl ester hydrochloride
- CBNumber
- CB4398811
- Molecular Formula
- C7H14ClNO2
- Formula Weight
- 179.64
- MOL File
- 32559-18-5.mol
METHYL PIPECOLINATE HYDROCHLORIDE Property
- Melting point:
- 205 °C (dec.)(lit.)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- 1S/C7H13NO2.ClH/c1-10-7(9)6-4-2-3-5-8-6;/h6,8H,2-5H2,1H3;1H
- InChIKey
- APCHKWZTSCBBJX-UHFFFAOYSA-N
- SMILES
- Cl.COC(=O)C1CCCCN1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 391204
- Product name
- Methyl pipecolinate hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $191
- Updated
- 2023/01/07
- Product number
- 391204
- Product name
- Methyl pipecolinate hydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $270
- Updated
- 2023/01/07
- Product number
- M329738
- Product name
- Methyl pipecolinate hydrochloride
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J94316
- Product name
- MethypipecolinateHCl
- Packaging
- 100g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- B019
- Product name
- MethypipecolinateHCl
- Packaging
- 100g
- Price
- $88
- Updated
- 2021/12/16
METHYL PIPECOLINATE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Methyl Pipecolinate Hydrochloride is a reactant for synthesis of a pipecolic linker and antiviral agents.
General Description
Methyl pipecolinate hydrochloride is a hydrochloride salt of methyl piperidine-2-carboxylate (methyl pipecolinate). The kinetics of the enzymatic separation of enantiomeric forms of methyl pipecolinate using Candida antarctica Lipase A (CAL-A) has been reported. Its role as catalyst for the standard Diels-Alder reaction has been examined.
Synthesis
67-56-1
4043-87-2
32559-18-5
Synthesis of methylpiperidine-2-carboxylic acid hydrochloride: methanol (1300 mL) was added to a 3000 mL three-necked round bottom flask. The reaction system was cooled to -30°C. Sulfoxide chloride (280 mL) was added slowly and dropwise under stirring conditions while keeping the temperature at -30 °C. Subsequently, piperidine-2-carboxylic acid (100 g, added in batches) was added to the reaction system and the mixture was cooled to 0 °C. The reaction was continuously stirred for 15 h at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was methanol and a few drops of ammonia were added). After completion of the reaction, the reaction mixture was concentrated under vacuum using a rotary evaporator. Toluene (100 mL) was added to the concentrate and kept under reflux conditions. The mixture was again concentrated under vacuum using a rotary evaporator. This toluene addition and concentration step was repeated twice. The final product was 137 g (98% yield) of methylpiperidine-2-carboxylic acid hydrochloride as a white solid.
References
[1] European Journal of Organic Chemistry, 2014, vol. 2014, # 29, p. 6467 - 6480
[2] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 38; 39
[3] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 5, p. 1199 - 1212
[4] Tetrahedron Letters, 2006, vol. 47, # 29, p. 5017 - 5020
[5] Chemistry - A European Journal, 2010, vol. 16, # 25, p. 7547 - 7553
METHYL PIPECOLINATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL PIPECOLINATE HYDROCHLORIDE manufacturers
- Product
- Methyl piperidine-2-carboxylate HCl 32559-18-5
- Price
- US $15.00-50.00/kg
- Min. Order
- 1kg
- Purity
- NLT98%
- Supply Ability
- 5 ton per month
- Release date
- 2023-04-02
- Product
- METHYL PIPECOLINATE HYDROCHLORIDE 32559-18-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 10tons
- Release date
- 2020-08-24
- Product
- METHYL PIPECOLINATE HYDROCHLORIDE 32559-18-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 448
- Release date
- 2019-09-01