ChemicalBook > CAS DataBase List > TRIMETHOBENZAMIDE HYDROCHLORIDE

TRIMETHOBENZAMIDE HYDROCHLORIDE

Product Name
TRIMETHOBENZAMIDE HYDROCHLORIDE
CAS No.
554-92-7
Chemical Name
TRIMETHOBENZAMIDE HYDROCHLORIDE
Synonyms
tigan;Trimethobenzamide HCL;ro2-9578;Tribenzagan HCl;tiganhydrochloride;LABOTEST-BB LT00772325;Tribenzagan Hydrochloride;TRIMETHOBENZAMIDE HYDROCHLORIDE;Trimethobenzamide HCl (Ro 2-9578);TRIMETHOBENZAMIDEHYDROCHLORIDE,USP
CBNumber
CB4712200
Molecular Formula
C21H29ClN2O5
Formula Weight
424.92
MOL File
554-92-7.mol
More
Less

TRIMETHOBENZAMIDE HYDROCHLORIDE Property

Melting point:
187.5-190°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
More
Less

Safety

WGK Germany 
3
HS Code 
2924296000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1692006
Product name
Trimethobenzamide hydrochloride
Packaging
200mg
Price
$491
Updated
2024/03/01
TCI Chemical
Product number
T3525
Product name
Trimethobenzamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$118
Updated
2024/03/01
TCI Chemical
Product number
T3525
Product name
Trimethobenzamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$352
Updated
2024/03/01
Cayman Chemical
Product number
24145
Product name
Trimethobenzamide (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
24145
Product name
Trimethobenzamide (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$111
Updated
2024/03/01
More
Less

TRIMETHOBENZAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Tigan,Beecham,US,1973

Uses

antiemetic

Uses

Trimethobenzamide Hydrochloride a pharmaceutical compound used in the prevention of nausea and vomiting in patients. Also used in the treatment of Parkinson’s disease.

Manufacturing Process

To 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams (1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and refluxed for 15 hours, then cooled and the precipitated sodium chloride filtered off. The filtrate was concentrated at steam temperature under water vacuum and the residual oil was fractionated in high vacuum, to give 4-(2- dimethylaminoethoxy)benzaldehyde, BP2.2145°C.
Two teaspoons of Raney nickel catalyst were added to a solution of 65.6 grams (0.34 mol) of 4-(2-dimethylaminoethoxy)benzaldehyde in 300 ml of 10% ammoniacal ethanol. The mixture was hydrogenated at 80°C and a pressure of 1,000 psi. The catalyst was filtered off, the volatiles were distilled off and the residual oil was fractionated in high vacuum, to obtain 4-(2- dimethylaminoethoxy)benzylamine, BP0.3120° to 123°C.
To 9.7 grams (0.05 mol) of 4-(2-dimethylaminoethoxy)benzylamine, dissolved in 100 ml of acetonitrile, was added all at once 12 grams (0.051 mol) of 3,4,5-trimethoxybenzoyl chloride, dissolved in 75 ml of acetonitrile. The mixture was stirred and refluxed for 8 hours, and then cooled. The crystalline solid, which had formed, was filtered off, washed with acetonitrile and recrystallized from acetonitrile, to give 4-(2-dimethylaminoethoxy)-N-(3,4,5- trimethoxybenzoyl)benzylamine hydrochloride, MP 185° to 186°C.

brand name

Tigan (King).

Therapeutic Function

Antinauseant

TRIMETHOBENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TRIMETHOBENZAMIDE HYDROCHLORIDE Suppliers

China 58 Germany 2 India 7 Japan 1 United Kingdom 2 United States 14 Global 84
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Artis Biotech Co. Ltd.
Tel
0575-0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
3213
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2839
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6037 18920794737
Email
sales@heowns.com
Country
China
ProdList
23083
Advantage
60
Shenzhen BST Science & Technology Co., Ltd.
Tel
sk618@163.com
Fax
+86 (755) 2553-9493
Email
sk618@163.com
Country
China
ProdList
54
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58
CHG Opto-Electronic Corporation Limited
Tel
2537653158 16621191650
Fax
QQ 2537653158
Email
2537653158@qq.com
Country
China
ProdList
7140
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9990
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10524
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-81120477 17792793610
Email
1033@dideu.com
Country
China
ProdList
10011
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
30016
Advantage
58
Pushan Industry (Shaanxi) Co., Ltd.
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Country
China
ProdList
10011
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
17730
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
4997
Advantage
58
guoyungurui
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
10335
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 18021050169
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
Advantage
58
Tel
Email
sangon@qq.com
Country
CHINA
ProdList
47239
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32965
Advantage
60
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6682
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6705
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
SCI Pharmtech, Inc.
Tel
--
Fax
--
Email
info@siegfried.ch
Country
China
ProdList
65
Advantage
74
Shanghai Yihui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
yihbio@163.com
Country
CHINA
ProdList
5667
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Shize Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shizezjp@163.com
Country
CHINA
ProdList
6174
Advantage
58

554-92-7, TRIMETHOBENZAMIDE HYDROCHLORIDERelated Search:

TRIMETHYL 1,3,5-BENZENETRICARBOXYLATE Itopride Itopride hydrochloride 3,4,5-Trimethoxybenzaldehyde 4-Hydroxy-3-methoxybenzylamine hydrochloride Trimethobenzamide 3,5-Dimethoxybenzamide 3,4,5-TRIHYDROXYBENZAMIDE Veratrylamine N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE 3,5-Dihydroxybenzamide N-BENZYLBENZAMIDE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE TRIMETHOBENZAMIDE HYDROCHLORIDE 3,5-DIMETHOXY-4-HYDROXYBENZAMIDE (3,5-DIMETHOXYBENZYL)METHYLAMINE 3,5-Dimethoxybenzylamine 3,4,5-Trimethoxybenzylamine

  • LABOTEST-BB LT00772325
  • TRIMETHOBENZAMIDE HYDROCHLORIDE
  • Tribenzagan Hydrochloride
  • N-([2-Dimethylaminoethoxy] benzyl)-3,4,5-trimethoxybenzamide hydrochloride
  • TRIMETHOBENZAMIDEHYDROCHLORIDE,USP
  • 4-(2-dimethylaminoethoxy)-n-(3,4,5-trimethoxybenzoyl)benzylaminehydrochlorid
  • n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamidehydrochloride
  • n-(p-(2-(dimethylamino)ethoxy)-benzyl)-3,4,5-trimethoxybenzamidemonohydrochl
  • n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamidhydrochlori
  • ro2-9578
  • tigan
  • tiganhydrochloride
  • N-(4-(2-dimethylaminoethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride
  • Trimethobenzamide HCL
  • N-{{4-[2-(Dimethylamino)ethoxy]phenyl}methyl}-3,4,5-trimethoxybenzamide monohydrochloride
  • Trimethobenzamide Hydrochloride (200 mg)
  • Trimethobenzamide Hydrochloride (500 mg)
  • TRIMETHOBENZAMIDE HYDROCHLORIDE USP/EP/BP
  • Trimethobenzamide HCl (Ro 2-9578)
  • Trimethobenzamide Hydrochloride (1692006)
  • Influenza Virus,inhibit,Dopamine Receptor,Trimethobenzamide hydrochloride,Inhibitor,Trimethobenzamide
  • Tribenzagan HCl
  • Trimethobenzamide hydrochloride, 10 mM in DMSO
  • 554-92-7
  • 544-92-7
  • C21H28N2O5ClH
  • C21H29ClN2O5
  • C21H28N2O5HCl
  • TIGAN