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TRIMETHOBENZAMIDE HYDROCHLORIDE

Product Name
TRIMETHOBENZAMIDE HYDROCHLORIDE
CAS No.
554-92-7
Chemical Name
TRIMETHOBENZAMIDE HYDROCHLORIDE
Synonyms
tigan;Trimethobenzamide HCL;ro2-9578;Tribenzagan HCl;tiganhydrochloride;LABOTEST-BB LT00772325;Tribenzagan Hydrochloride;TRIMETHOBENZAMIDE HYDROCHLORIDE;Trimethobenzamide HCl (Ro 2-9578);TRIMETHOBENZAMIDEHYDROCHLORIDE,USP
CBNumber
CB4712200
Molecular Formula
C21H29ClN2O5
Formula Weight
424.92
MOL File
554-92-7.mol
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TRIMETHOBENZAMIDE HYDROCHLORIDE Property

Melting point:
187.5-190°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
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Safety

WGK Germany 
3
HS Code 
2924296000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1692006
Product name
Trimethobenzamide hydrochloride
Packaging
200mg
Price
$465
Updated
2025/07/31
TCI Chemical
Product number
T3525
Product name
Trimethobenzamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$106
Updated
2025/07/31
TCI Chemical
Product number
T3525
Product name
Trimethobenzamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$317
Updated
2025/07/31
Cayman Chemical
Product number
24145
Product name
Trimethobenzamide (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
24145
Product name
Trimethobenzamide (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$111
Updated
2024/03/01
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TRIMETHOBENZAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Tigan,Beecham,US,1973

Uses

antiemetic

Uses

Trimethobenzamide Hydrochloride a pharmaceutical compound used in the prevention of nausea and vomiting in patients. Also used in the treatment of Parkinson’s disease.

Manufacturing Process

To 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams (1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and refluxed for 15 hours, then cooled and the precipitated sodium chloride filtered off. The filtrate was concentrated at steam temperature under water vacuum and the residual oil was fractionated in high vacuum, to give 4-(2- dimethylaminoethoxy)benzaldehyde, BP2.2145°C.
Two teaspoons of Raney nickel catalyst were added to a solution of 65.6 grams (0.34 mol) of 4-(2-dimethylaminoethoxy)benzaldehyde in 300 ml of 10% ammoniacal ethanol. The mixture was hydrogenated at 80°C and a pressure of 1,000 psi. The catalyst was filtered off, the volatiles were distilled off and the residual oil was fractionated in high vacuum, to obtain 4-(2- dimethylaminoethoxy)benzylamine, BP0.3120° to 123°C.
To 9.7 grams (0.05 mol) of 4-(2-dimethylaminoethoxy)benzylamine, dissolved in 100 ml of acetonitrile, was added all at once 12 grams (0.051 mol) of 3,4,5-trimethoxybenzoyl chloride, dissolved in 75 ml of acetonitrile. The mixture was stirred and refluxed for 8 hours, and then cooled. The crystalline solid, which had formed, was filtered off, washed with acetonitrile and recrystallized from acetonitrile, to give 4-(2-dimethylaminoethoxy)-N-(3,4,5- trimethoxybenzoyl)benzylamine hydrochloride, MP 185° to 186°C.

brand name

Tigan (King).

Therapeutic Function

Antinauseant

TRIMETHOBENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIMETHOBENZAMIDE HYDROCHLORIDE Suppliers

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554-92-7, TRIMETHOBENZAMIDE HYDROCHLORIDERelated Search:

TRIMETHYL 1,3,5-BENZENETRICARBOXYLATE Itopride Itopride hydrochloride 3,4,5-Trimethoxybenzaldehyde 4-Hydroxy-3-methoxybenzylamine hydrochloride Trimethobenzamide 3,5-Dimethoxybenzamide 3,4,5-TRIHYDROXYBENZAMIDE Veratrylamine N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE 3,5-Dihydroxybenzamide N-BENZYLBENZAMIDE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE TRIMETHOBENZAMIDE HYDROCHLORIDE 3,5-DIMETHOXY-4-HYDROXYBENZAMIDE (3,5-DIMETHOXYBENZYL)METHYLAMINE 3,5-Dimethoxybenzylamine 3,4,5-Trimethoxybenzylamine

  • LABOTEST-BB LT00772325
  • TRIMETHOBENZAMIDE HYDROCHLORIDE
  • Tribenzagan Hydrochloride
  • N-([2-Dimethylaminoethoxy] benzyl)-3,4,5-trimethoxybenzamide hydrochloride
  • TRIMETHOBENZAMIDEHYDROCHLORIDE,USP
  • 4-(2-dimethylaminoethoxy)-n-(3,4,5-trimethoxybenzoyl)benzylaminehydrochlorid
  • n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamidehydrochloride
  • n-(p-(2-(dimethylamino)ethoxy)-benzyl)-3,4,5-trimethoxybenzamidemonohydrochl
  • n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamidhydrochlori
  • ro2-9578
  • tigan
  • tiganhydrochloride
  • N-(4-(2-dimethylaminoethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride
  • Trimethobenzamide HCL
  • N-{{4-[2-(Dimethylamino)ethoxy]phenyl}methyl}-3,4,5-trimethoxybenzamide monohydrochloride
  • Trimethobenzamide Hydrochloride (200 mg)
  • Trimethobenzamide Hydrochloride (500 mg)
  • TRIMETHOBENZAMIDE HYDROCHLORIDE USP/EP/BP
  • Trimethobenzamide HCl (Ro 2-9578)
  • Trimethobenzamide Hydrochloride (1692006)
  • Influenza Virus,inhibit,Dopamine Receptor,Trimethobenzamide hydrochloride,Inhibitor,Trimethobenzamide
  • Tribenzagan HCl
  • Trimethobenzamide hydrochloride, 10 mM in DMSO
  • 554-92-7
  • 544-92-7
  • C21H28N2O5ClH
  • C21H29ClN2O5
  • C21H28N2O5HCl
  • TIGAN