L-655,240

Product Name: L-655,240
CAS No.: 103253-15-2
Chemical Name: L-655,240
Synonyms: L-655;L-655,240;L 655,240,L655,240;JLPYLHLUHJOPNL-UHFFFAOYSA-N;1-(4-Chlorobenzyl)-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid;1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid;1-[(4-CHLOROPHENYL)METHYL]-5-FLUORO-A,A,3-TRIMETHYL-1H-INDOLE-2-PROPANOIC ACID;3-[1-(4-CHLOROBENZYL)-5-FLUORO-3-METHYL-INDOL-2-YL]-2,2-DIMETHYL PROPANOIC ACID;1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-;1-((4-Chlorophenyl)methyl)-5-fluoro-alpha,alpha-3-trimethyl-(1H)-indole-2-propanoicacid
CBNumber: CB4718318
Molecular Formula: C21H21ClFNO2
Formula Weight: 373.85
MOL File: 103253-15-2.mol

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L-655,240 Property

Boiling point:: 548.7±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: 30 mg/mL
form: solid
pka: 4.82±0.10(Predicted)
color: off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10011562
Product name: L-655,240
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2021/12/16

Cayman Chemical

Product number: 10011562
Product name: L-655,240
Purity: ≥98%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

Cayman Chemical

Product number: 10011562
Product name: L-655,240
Purity: ≥98%
Packaging: 10mg
Price: $384
Updated: 2021/12/16

Cayman Chemical

Product number: 10011562
Product name: L-655,240
Purity: ≥98%
Packaging: 25mg
Price: $840
Updated: 2021/12/16

TRC

Product number: L009505
Product name: L-655,240
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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L-655,240 Chemical Properties,Usage,Production

Uses

L-655,240 is a selective and potent thromboxane and prostaglandin endoperoxide antagonist. Also used in the structure-based and ligand-based drug design for microsomal prostaglandins E synthase-1 inhibitors.

Definition

ChEBI: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methyl-2-indolyl]-2,2-dimethylpropanoic acid is a methylindole.

Biological Activity

Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist. pA 2 values are 8-8.4 in guinea pig smooth muscle; IC 50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo .

in vivo

L 655240 (0.3 mg/kg; i.v.; single dose) changes heat rate, arterial and pulmonary arterial blood pressure, and cardiac output in canine model^[1].

L-655,240 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-655,240 Suppliers

CHINA 26 Germany 2 Switzerland 1 United Kingdom 1 United States 7 USA 1 Global 38

3B Pharmachem (Wuhan) International Co.,Ltd.

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103253-15-2, L-655,240Related Search:

L-655,240

1-((4-Chlorophenyl)methyl)-5-fluoro-alpha,alpha-3-trimethyl-(1H)-indole-2-propanoicacid

1-(4-Chlorobenzyl)-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid

1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid

3-[1-(4-CHLOROBENZYL)-5-FLUORO-3-METHYL-INDOL-2-YL]-2,2-DIMETHYL PROPANOIC ACID

1-[(4-CHLOROPHENYL)METHYL]-5-FLUORO-A,A,3-TRIMETHYL-1H-INDOLE-2-PROPANOIC ACID

JLPYLHLUHJOPNL-UHFFFAOYSA-N

1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-

L-655

L 655,240,L655,240

103253-15-2

C21H21ClFNO2

C21H21O2NClF

Prostanoid receptor and related