3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE

3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE Property

Melting point:

90 °C

Boiling point:

201.2±50.0 °C(Predicted)

Density 

1.62±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

form 

solid

pka

7.83±0.70(Predicted)

color 

Pale brown

CAS DataBase Reference

89570-82-1(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,T

Risk Statements 

20/21/22-36/37/38-25

Safety Statements 

20/21-36/37/39-45

RIDADR 

UN2811

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 3-chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine from 2,3-dichloro-5-(trifluoromethyl)pyridine: Hydrazine hydrate (3.15 g) was slowly added to a solution of ethanol (50 mL) containing 2,3-dichloro-5-(trifluoromethyl)pyridine (6.8 g) under ice-bath conditions. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The resulting residue was treated with isopropyl ether (IPE) and the precipitated solid was collected by filtration to give the final target product 3-chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine (7.57 g). Mass spectral analysis (APCI+): [M+H]+ m/z 212.0.

References

[1] Heterocycles, 1984, vol. 22, # 1, p. 117 - 124
[2] Organic and Biomolecular Chemistry, 2004, vol. 2, # 2, p. 246 - 256
[3] Patent: US5321002, 1994, A
[4] Patent: US2015/266872, 2015, A1. Location in patent: Paragraph 0685; 0686
[5] Letters in Drug Design and Discovery, 2016, vol. 13, # 4, p. 324 - 328