3-Chloro-5-(trifluoromethyl)pyridine

Product Name: 3-Chloro-5-(trifluoromethyl)pyridine
CAS No.: 85148-26-1
Chemical Name: 3-Chloro-5-(trifluoromethyl)pyridine
Synonyms: 3-TRIFLUOROMETHYL-5-CHLOROPYRIDINE;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-5-(trifluoroMethyl)-;3-Chloro-5-(trifluoromethyl)pyridine97%;3-Chloro-5-(trifluoromethyl)pyridine 97%;3-Chloro-5-(trifluoromethyl)pyridine >3-Chloro-5-(trifluoromethyl)pyridine ISO 9001：2015 REACH
CBNumber: CB4468417
Molecular Formula: C6H3ClF3N
Formula Weight: 181.54
MOL File: 85148-26-1.mol

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3-Chloro-5-(trifluoromethyl)pyridine Property

Melting point:: 131.5 °C
Boiling point:: 144°C
Density: 1.416±0.06 g/cm3(Predicted)
refractive index: 1.4460 to 1.4500
Flash point:: 54℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 0.52±0.20(Predicted)
Appearance: Colorless to off-white <23°C Solid,>27°C Liquid
InChI: InChI=1S/C6H3ClF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H
InChIKey: OMRCXTBFBBWTDL-UHFFFAOYSA-N
SMILES: C1=NC=C(C(F)(F)F)C=C1Cl

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Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 20/21/22-36/37/38-25
Safety Statements: 26-36/37/39-36-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, IRRITANT-HARMFUL
HazardClass: 6.1
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 714488
Product name: 3-Chloro-5-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 1g
Price: $91.2
Updated: 2023/06/20

TCI Chemical

Product number: C2951
Product name: 3-Chloro-5-(trifluoromethyl)pyridine
Purity: >97.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: C2951
Product name: 3-Chloro-5-(trifluoromethyl)pyridine
Purity: >97.0%(GC)
Packaging: 5g
Price: $119
Updated: 2025/07/31

TRC

Product number: B427928
Product name: 3-chloro-5-(trifluoromethyl)pyridine
Packaging: 1g
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W8792
Product name: 3-Chloro-5-(trifluoromethyl)pyridine
Packaging: 1g
Price: $72
Updated: 2021/12/16

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3-Chloro-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline

Uses

3-Chloro-5-(trifluoromethyl)pyridine (3CTFP) is a pyridinium salt that is a byproduct of the production of chlorofluorocarbons. It is used to reduce the level of chlorine in water, and it can be used as a pesticide. 3CTFP is also an anion that can be reduced to form the chloride ion. 3CTFP reacts with nucleophiles such as ammonia or amines, which leads to nucleophilic substitution reactions. This reaction can be reversed by adding acid. The product from this reaction is ammonia gas.

Synthesis

69045-84-7

85148-26-1

The general procedure for the synthesis of 3-chloro-5-trifluoromethylpyridine using 2,3-dichloro-5-trifluoromethylpyridine as starting material was as follows: zinc powder (1.18 g, 18.0 mmol) was added to a suspension of 2,3-dichloro-5-trifluoromethylpyridine (2.0 g, 9.30 mmol) in a solvent mixture of 80:20 (v/v) water and acetic acid (5 mL) at 90° C with stirring for 1 hour. Subsequently, zinc powder (1 g, 15.3 mmol) was made up and stirring was continued at 90°C for 15 minutes. After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was washed with dichloromethane. The filtrate was carefully concentrated and the residue was purified by silica gel column chromatography with an elution gradient of 100:0 to 0:100 (v/v) hexane:dichloromethane, resulting in 3-chloro-5-trifluoromethylpyridine as a colorless oil (0.120 g, 7% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.93 (s, 1H), 8.78 (s, 2H); GC-MS (EI) analysis showed m/z = 181.0, 183.0 [M].

References

[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163

3-Chloro-5-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Chlorfluazuron

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3-Chloro-5-(trifluoromethyl)pyridine Suppliers

Americas 1 Belgium 2 China 179 Europe 1 France 2 Germany 6 India 6 Italy 1 Japan 2 The Netherlands 1 United Kingdom 9 United States 35 Global 245

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View Lastest Price from 3-Chloro-5-(trifluoromethyl)pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Henan Fengda Chemical Co., Ltd

Product: 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

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3-Chloro-5-(trifluoromethyl)pyridine ISO 9001：2015 REACH

85148-26-1

Fluorine series

alkyl chloride

pharmacetical

Pyridine

Pyridine series