3-Chloro-5-(trifluoromethyl)pyridine
- Product Name
- 3-Chloro-5-(trifluoromethyl)pyridine
- CAS No.
- 85148-26-1
- Chemical Name
- 3-Chloro-5-(trifluoromethyl)pyridine
- Synonyms
- 3-TRIFLUOROMETHYL-5-CHLOROPYRIDINE;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-5-(trifluoroMethyl)-;3-Chloro-5-(trifluoromethyl)pyridine97%;3-Chloro-5-(trifluoromethyl)pyridine 97%;3-Chloro-5-(trifluoromethyl)pyridine >3-Chloro-5-(trifluoromethyl)pyridine ISO 9001：2015 REACH
- CBNumber
- CB4468417
- Molecular Formula
- C6H3ClF3N
- Formula Weight
- 181.54
- MOL File
- 85148-26-1.mol
3-Chloro-5-(trifluoromethyl)pyridine Property
- Melting point:
- 131.5 °C
- Boiling point:
- 144°C
- Density
- 1.416±0.06 g/cm3(Predicted)
- refractive index
- 1.4460 to 1.4500
- Flash point:
- 54℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 0.52±0.20(Predicted)
- Appearance
- Colorless to off-white <23°C Solid,>27°C Liquid
- InChI
- InChI=1S/C6H3ClF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H
- InChIKey
- OMRCXTBFBBWTDL-UHFFFAOYSA-N
- SMILES
- C1=NC=C(C(F)(F)F)C=C1Cl
Safety
- Hazard Codes
- Xi,Xn,T
- Risk Statements
- 20/21/22-36/37/38-25
- Safety Statements
- 26-36/37/39-36-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 714488
- Product name
- 3-Chloro-5-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $91.2
- Updated
- 2023/06/20
- Product number
- C2951
- Product name
- 3-Chloro-5-(trifluoromethyl)pyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- C2951
- Product name
- 3-Chloro-5-(trifluoromethyl)pyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- B427928
- Product name
- 3-chloro-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W8792
- Product name
- 3-Chloro-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
3-Chloro-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production
Chemical Properties
light yellow crystalline
Uses
3-Chloro-5-(trifluoromethyl)pyridine (3CTFP) is a pyridinium salt that is a byproduct of the production of chlorofluorocarbons. It is used to reduce the level of chlorine in water, and it can be used as a pesticide. 3CTFP is also an anion that can be reduced to form the chloride ion. 3CTFP reacts with nucleophiles such as ammonia or amines, which leads to nucleophilic substitution reactions. This reaction can be reversed by adding acid. The product from this reaction is ammonia gas.
Synthesis
69045-84-7
85148-26-1
The general procedure for the synthesis of 3-chloro-5-trifluoromethylpyridine using 2,3-dichloro-5-trifluoromethylpyridine as starting material was as follows: zinc powder (1.18 g, 18.0 mmol) was added to a suspension of 2,3-dichloro-5-trifluoromethylpyridine (2.0 g, 9.30 mmol) in a solvent mixture of 80:20 (v/v) water and acetic acid (5 mL) at 90° C with stirring for 1 hour. Subsequently, zinc powder (1 g, 15.3 mmol) was made up and stirring was continued at 90°C for 15 minutes. After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was washed with dichloromethane. The filtrate was carefully concentrated and the residue was purified by silica gel column chromatography with an elution gradient of 100:0 to 0:100 (v/v) hexane:dichloromethane, resulting in 3-chloro-5-trifluoromethylpyridine as a colorless oil (0.120 g, 7% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.93 (s, 1H), 8.78 (s, 2H); GC-MS (EI) analysis showed m/z = 181.0, 183.0 [M].
References
[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163
3-Chloro-5-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5-(trifluoromethyl)pyridine Suppliers
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- Belgium
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View Lastest Price from 3-Chloro-5-(trifluoromethyl)pyridine manufacturers
- Product
- 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 3-Chloro-5-(trifluoromethyl)pyridine 85148-26-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08