3,5-DIFLUORO-2-NITROBENZOIC ACID
- Product Name
- 3,5-DIFLUORO-2-NITROBENZOIC ACID
- CAS No.
- 331765-71-0
- Chemical Name
- 3,5-DIFLUORO-2-NITROBENZOIC ACID
- Synonyms
- BUTTPARK 51\07-01;3,5-DIFLUORO-2-NITROBENZOIC ACID;2-Carboxy-4,6-difluoronitrobenzene;Benzoic acid, 3,5-difluoro-2-nitro-
- CBNumber
- CB4720340
- Molecular Formula
- C7H3F2NO4
- Formula Weight
- 203.1
- MOL File
- Mol file
3,5-DIFLUORO-2-NITROBENZOIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- color
- Lumpy, off white to beige
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D458370
- Product name
- 3,5-Difluoro-2-nitrobenzoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D458370
- Product name
- 3,5-Difluoro-2-nitrobenzoicAcid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D458370
- Product name
- 3,5-Difluoro-2-nitrobenzoicAcid
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- PC0922
- Product name
- 3,5-Difluoro-2-nitrobenzoicacid
- Packaging
- 25g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- 3811AB
- Product name
- 3,5-Difluoro-2-nitrobenzoicacid
- Packaging
- 5g
- Price
- $371
- Updated
- 2021/12/16
3,5-DIFLUORO-2-NITROBENZOIC ACID Chemical Properties,Usage,Production
Synthesis
455-40-3
331765-71-0
Step 1: 3,5-difluorobenzoic acid (80 g, 506 mmol) was stirred with concentrated sulfuric acid (250 mL) for 1 hour at room temperature. Subsequently, concentrated nitric acid (90 mL) was added slowly and dropwise while the reaction temperature was controlled below 45 °C by a water bath. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by slowly pouring the reaction solution into crushed ice, the precipitated solid was collected by filtration and washed thoroughly with cold water to afford 3,5-difluoro-2-nitrobenzoic acid (compound 273) as a white solid (93.0 g, 91% yield). The product could be used directly in the subsequent reaction without further purification.1H NMR (400 MHz, DMSO-d6) δ 8.01 (ddd, J = 10.9, 8.5, 2.8 Hz, 1H), 7.71 (dt, J = 8.4, 2.2 Hz, 1H).
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 234
[2] Patent: EP1214299, 2004, B1. Location in patent: Page 18
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 7, p. 2733 - 2743
3,5-DIFLUORO-2-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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