ChemicalBook > CAS DataBase List > 3,5-DIFLUORO-2-NITROBENZOIC ACID

3,5-DIFLUORO-2-NITROBENZOIC ACID

Product Name
3,5-DIFLUORO-2-NITROBENZOIC ACID
CAS No.
331765-71-0
Chemical Name
3,5-DIFLUORO-2-NITROBENZOIC ACID
Synonyms
BUTTPARK 51\07-01;3,5-DIFLUORO-2-NITROBENZOIC ACID;2-Carboxy-4,6-difluoronitrobenzene;Benzoic acid, 3,5-difluoro-2-nitro-
CBNumber
CB4720340
Molecular Formula
C7H3F2NO4
Formula Weight
203.1
MOL File
Mol file
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3,5-DIFLUORO-2-NITROBENZOIC ACID Property

storage temp. 
Sealed in dry,Room Temperature
form 
powder
color 
Lumpy, off white to beige
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D458370
Product name
3,5-Difluoro-2-nitrobenzoicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
D458370
Product name
3,5-Difluoro-2-nitrobenzoicAcid
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
D458370
Product name
3,5-Difluoro-2-nitrobenzoicAcid
Packaging
500mg
Price
$240
Updated
2021/12/16
Apolloscientific
Product number
PC0922
Product name
3,5-Difluoro-2-nitrobenzoicacid
Packaging
1g
Price
$32
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-3-47
Product name
3,5-Difluoro-2-nitrobenzoic acid
Packaging
1g
Price
$36
Updated
2021/12/16
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3,5-DIFLUORO-2-NITROBENZOIC ACID Chemical Properties,Usage,Production

Synthesis

455-40-3

331765-71-0

Step 1: 3,5-difluorobenzoic acid (80 g, 506 mmol) was stirred with concentrated sulfuric acid (250 mL) for 1 hour at room temperature. Subsequently, concentrated nitric acid (90 mL) was added slowly and dropwise while the reaction temperature was controlled below 45 °C by a water bath. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by slowly pouring the reaction solution into crushed ice, the precipitated solid was collected by filtration and washed thoroughly with cold water to afford 3,5-difluoro-2-nitrobenzoic acid (compound 273) as a white solid (93.0 g, 91% yield). The product could be used directly in the subsequent reaction without further purification.1H NMR (400 MHz, DMSO-d6) δ 8.01 (ddd, J = 10.9, 8.5, 2.8 Hz, 1H), 7.71 (dt, J = 8.4, 2.2 Hz, 1H).

References

[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 234
[2] Patent: EP1214299, 2004, B1. Location in patent: Page 18
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 7, p. 2733 - 2743

3,5-DIFLUORO-2-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DIFLUORO-2-NITROBENZOIC ACID Suppliers

China 55 France 1 India 1 Italy 1 United Kingdom 4 United States 6 Global 68
Apollo Scientific Ltd.
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sales@apolloscientific.co.uk
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United Kingdom
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Fluorochem Ltd.
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enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
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74
Fluorochem Ltd
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vernam@fluorochem.co.uk
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United Kingdom
ProdList
6375
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Butt Park Ltd.
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113707.50@compuserve.com
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United Kingdom
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331765-71-0, 3,5-DIFLUORO-2-NITROBENZOIC ACIDRelated Search:


  • 3,5-DIFLUORO-2-NITROBENZOIC ACID
  • BUTTPARK 51\07-01
  • 2-Carboxy-4,6-difluoronitrobenzene
  • Benzoic acid, 3,5-difluoro-2-nitro-
  • 331765-71-0