3-MATIDA Property

storage temp. 

Store at +4°C

solubility 

Soluble to 100 mM in 1eq. NaOH and to 50 mM in DMSO

form 

Powder

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-MATIDA Chemical Properties,Usage,Production

Uses

3-MATIDA is a potent mGluR-1 antagonist.

Definition

ChEBI: 5-[amino(carboxy)methyl]-4-methyl-2-thiophenecarboxylic acid is an alpha-amino acid.

Biological Activity

Potent metabotropic glutamate mGlu 1 receptor antagonist (IC 50 = 6.3 μ M at rat mGlu 1a ). Displays ≥ 40-fold selectivity over other receptors: mGlu 5 , mGlu 2 , mGlu 4a (IC 50 > 300 μ M), NMDA and AMPA (IC 50 = 250 μ M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro . Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo .