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DESIPRAMINE HYDROCHLORIDE

Product Name
DESIPRAMINE HYDROCHLORIDE
CAS No.
58-28-6
Chemical Name
DESIPRAMINE HYDROCHLORIDE
Synonyms
ex4355;g35020;jb8181;Petylyl;Nortimil;RMI-9384A;norpramin;pertofran;nsc-114901;pertofrane
CBNumber
CB4723947
Molecular Formula
C18H23ClN2
Formula Weight
302.84
MOL File
58-28-6.mol
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DESIPRAMINE HYDROCHLORIDE Property

Melting point:
214-2160C
Flash point:
11 °C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25
Safety Statements 
7-16-36/37-45-26-24-22
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
RTECS 
HO0525000
HS Code 
2933996100
Toxicity
LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3900
Product name
Desipramine hydrochloride
Purity
≥98% (TLC), powder
Packaging
1g
Price
$55.1
Updated
2024/03/01
Sigma-Aldrich
Product number
D-906
Product name
Desipramine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$27.7
Updated
2024/03/01
Sigma-Aldrich
Product number
BP931
Product name
Desipramine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1172006
Product name
Desipramine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
D3900
Product name
Desipramine hydrochloride
Purity
≥98% (TLC), powder
Packaging
5g
Price
$194
Updated
2024/03/01
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DESIPRAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White To Off-White Solid

Originator

Pertofran,Geigy,UK,1963

Uses

Desipramine hydrochloride has been used:

  • to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
  • to protect unselective damage to the?noradrenergic system
  • as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Uses

Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Uses

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Definition

ChEBI: The hydrochloride salt of desipramine.

Manufacturing Process

Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.

brand name

Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).

Therapeutic Function

Psychostimulant

General Description

The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.

storage

Desiccate at +4°C

DESIPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DESIPRAMINE HYDROCHLORIDE Suppliers

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View Lastest Price from DESIPRAMINE HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
DESIPRAMINE HYDROCHLORIDE 58-28-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Career Henan Chemical Co
Product
DESIPRAMINE HYDROCHLORIDE 58-28-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

58-28-6, DESIPRAMINE HYDROCHLORIDERelated Search:

Clomipramine LOFEPRAMINE HYDROCHLORIDE LOFEPRAMINE carpipramine dihydrochloride Imipramine hydrochloride IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D DESIPRAMINE HYDROCHLORIDE Clomipramine hydrochloride MOSAPRAMINE DESIPRAMINE 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE IMIPRAMINE-2,4,6,8-D4 HCL IMIPRAMINE HYDROCHLORIDE, [N-METHYL-3H] 8-hydroxyclomipramine NORCLOMIPRAMINE DESMETHYLIMIPRAMINE HCL, [BENZENE RING-10,11-3H]- DESIPRAMINE HCL (D4)

  • Desipramine solution hydrochloride
  • RMI-9384A
  • 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride
  • Desipramine Hydrochloride (125 mg)
  • Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr)
  • 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride
  • 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
  • 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
  • demethylimipraminehydrochloride
  • desmethylimipraminehydrochloride
  • dmihydrochloride
  • ex4355
  • f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(hydrochlorid
  • f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(monohydrochlor
  • g35020
  • imipraminedemethylhydrochloride
  • jb8181
  • Petylyl
  • 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
  • DESIPRAMINEHYDROCHLORIDE,USP
  • 3-(5,6-dihydrobenzo[b][1
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine hydrochloride
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine hydrochloride
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amine
  • Desimipramine-hydrochloride
  • DesipraMine Monohydrochloride
  • Desipramine hydrochloride solution
  • [3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride
  • Imipramine EP Impurity A
  • Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride
  • Imipramine Impurity 1（Imipramine EP Impurity A）
  • n-(gamma-methylaminopropyl)iminodibenzylhydrochloride
  • norpramin
  • nsc-114901
  • pertofran
  • pertofrane
  • DESIPRAMINE HCL
  • DESIPRAMINE HYDROCHLORIDE
  • 10,11-DIHYDRO-N-METHYL-5-H-DIBENZ-[B,F]AZEPINE HYDROCHLORIDE
  • DESIPRAMINE HYDROCHLORIDE METHANOL*SOLUT ION
  • 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
  • Nortimil
  • Desipramine hydrochloride Solution, 1000ppm
  • Desipramine hydrochloride Solution, 100ppm
  • Desipramine hydrochloride CRS
  • (3-{2-azatricyclo[9.4.0.0,?]pentadeca-1(11),3(8),4,6 ,12,14-hexaen-2-yl}propyl)(methyl)amine hydrochloride
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride
  • esipraminehydrochloride
  • DESIPRAMINE HYDROCHLORIDE USP/EP/BP
  • Desipramine oxalate salt
  • Desipramine Hydrochloride (1.0 mg/mL in Methanol)
  • Desipramine HydrochlorideQ: What is Desipramine Hydrochloride Q: What is the CAS Number of Desipramine Hydrochloride Q: What is the storage condition of Desipramine Hydrochloride Q: What are the applications of Desipramine Hydrochloride
  • Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride
  • Desipramine Hydrochloride (1172006)
  • Imipramine Hydrochloride Impurity A as Hydrochloride
  • Imipramine Hydrochloride EP Impurity A as Hydrochloride