ChemicalBook > CAS DataBase List > DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE

Product Name
DESIPRAMINE HYDROCHLORIDE
CAS No.
58-28-6
Chemical Name
DESIPRAMINE HYDROCHLORIDE
Synonyms
ex4355;g35020;jb8181;Petylyl;Nortimil;RMI-9384A;norpramin;pertofran;nsc-114901;pertofrane
CBNumber
CB4723947
Molecular Formula
C18H23ClN2
Formula Weight
302.84
MOL File
58-28-6.mol
More
Less

DESIPRAMINE HYDROCHLORIDE Property

Melting point:
214-2160C
Flash point:
11 °C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Soluble to 100 mM in water
More
Less

Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25
Safety Statements 
7-16-36/37-45-26-24-22
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
RTECS 
HO0525000
HS Code 
2933996100
Toxicity
LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3900
Product name
Desipramine hydrochloride
Purity
≥98% (TLC), powder
Packaging
1g
Price
$55.1
Updated
2024/03/01
Sigma-Aldrich
Product number
D-906
Product name
Desipramine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$27.7
Updated
2024/03/01
Sigma-Aldrich
Product number
BP931
Product name
Desipramine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1172006
Product name
Desipramine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
D3900
Product name
Desipramine hydrochloride
Purity
≥98% (TLC), powder
Packaging
5g
Price
$194
Updated
2024/03/01
More
Less

DESIPRAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White To Off-White Solid

Originator

Pertofran,Geigy,UK,1963

Uses

Desipramine hydrochloride has been used:

  • to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
  • to protect unselective damage to the?noradrenergic system
  • as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Uses

Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Uses

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Definition

ChEBI: The hydrochloride salt of desipramine.

Manufacturing Process

Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.

brand name

Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).

Therapeutic Function

Psychostimulant

General Description

The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.

storage

Desiccate at +4°C

DESIPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DESIPRAMINE HYDROCHLORIDE Suppliers

Canada 1 China 104 Europe 2 France 3 Germany 1 India 7 Italy 1 Japan 1 Switzerland 1 United Kingdom 6 United States 25 Global 152
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653713
Email
xingui2022@126.com
Country
China
ProdList
10028
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
Hangzhou ChangCun Biotechnology Co., Ltd.
Tel
0571-; 13567100326
Fax
QQ158848739
Email
158848739@qq.com
Country
China
ProdList
108
Advantage
50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Chengdu MassCale Pharmaceutical Co., Ltd.
Tel
028-84552636 18084815636
Email
chensfsc@126.com
Country
China
ProdList
1445
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22787
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9911
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15352
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9919
Advantage
12
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9976
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5176
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29810
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58
PCL - Business, Laboratory Pharmaceutical
Tel
19150123681
Fax
QQ:3008022628
Email
Hu.xinyue@purechemland.com
Country
China
ProdList
3566
Advantage
58
Advanced chemblocks inc
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
10784
Advantage
58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
8084
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-020-3846236 17688849268
Email
2443244976@qq.com
Country
China
ProdList
7775
Advantage
58
Zhuhai Anzhe Biotechnology Co,Ltd.
Tel
13169972583
Email
513211116@qq.com
Country
China
ProdList
3006
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9244
Advantage
58
Shanghai Chemisci Technology Co., Ltd
Tel
021-58690851 15690882017
Email
1877080091@qq.com
Country
China
ProdList
7521
Advantage
58
Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 15152877458
Fax
0513-68669626
Email
feiyubio@163.com
Country
China
ProdList
4819
Advantage
58
More
Less

View Lastest Price from DESIPRAMINE HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
DESIPRAMINE HYDROCHLORIDE 58-28-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Career Henan Chemical Co
Product
DESIPRAMINE HYDROCHLORIDE 58-28-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

58-28-6, DESIPRAMINE HYDROCHLORIDERelated Search:

Clomipramine LOFEPRAMINE HYDROCHLORIDE LOFEPRAMINE carpipramine dihydrochloride Imipramine hydrochloride IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D DESIPRAMINE HYDROCHLORIDE Clomipramine hydrochloride MOSAPRAMINE DESIPRAMINE 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE IMIPRAMINE-2,4,6,8-D4 HCL IMIPRAMINE HYDROCHLORIDE, [N-METHYL-3H] 8-hydroxyclomipramine NORCLOMIPRAMINE DESMETHYLIMIPRAMINE HCL, [BENZENE RING-10,11-3H]- DESIPRAMINE HCL (D4)

  • Desipramine solution hydrochloride
  • RMI-9384A
  • 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride
  • Desipramine Hydrochloride (125 mg)
  • Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr)
  • 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride
  • 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
  • 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
  • demethylimipraminehydrochloride
  • desmethylimipraminehydrochloride
  • dmihydrochloride
  • ex4355
  • f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(hydrochlorid
  • f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(monohydrochlor
  • g35020
  • imipraminedemethylhydrochloride
  • jb8181
  • Petylyl
  • 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
  • DESIPRAMINEHYDROCHLORIDE,USP
  • 3-(5,6-dihydrobenzo[b][1
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine hydrochloride
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine hydrochloride
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amine
  • Desimipramine-hydrochloride
  • DesipraMine Monohydrochloride
  • Desipramine hydrochloride solution
  • [3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride
  • Imipramine EP Impurity A
  • Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride
  • Imipramine Impurity 1（Imipramine EP Impurity A）
  • n-(gamma-methylaminopropyl)iminodibenzylhydrochloride
  • norpramin
  • nsc-114901
  • pertofran
  • pertofrane
  • DESIPRAMINE HCL
  • DESIPRAMINE HYDROCHLORIDE
  • 10,11-DIHYDRO-N-METHYL-5-H-DIBENZ-[B,F]AZEPINE HYDROCHLORIDE
  • DESIPRAMINE HYDROCHLORIDE METHANOL*SOLUT ION
  • 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
  • Nortimil
  • Desipramine hydrochloride Solution, 1000ppm
  • Desipramine hydrochloride Solution, 100ppm
  • Desipramine hydrochloride CRS
  • (3-{2-azatricyclo[9.4.0.0,?]pentadeca-1(11),3(8),4,6 ,12,14-hexaen-2-yl}propyl)(methyl)amine hydrochloride
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride
  • esipraminehydrochloride
  • DESIPRAMINE HYDROCHLORIDE USP/EP/BP
  • Desipramine oxalate salt
  • Desipramine Hydrochloride (1.0 mg/mL in Methanol)
  • Desipramine HydrochlorideQ: What is Desipramine Hydrochloride Q: What is the CAS Number of Desipramine Hydrochloride Q: What is the storage condition of Desipramine Hydrochloride Q: What are the applications of Desipramine Hydrochloride
  • Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride
  • Desipramine Hydrochloride (1172006)
  • Imipramine Hydrochloride Impurity A as Hydrochloride
  • Imipramine Hydrochloride EP Impurity A as Hydrochloride