ChemicalBook > CAS DataBase List > AG 1478 HYDROCHLORIDE

AG 1478 HYDROCHLORIDE

Product Name
AG 1478 HYDROCHLORIDE
CAS No.
153436-53-4
Chemical Name
AG 1478 HYDROCHLORIDE
Synonyms
-1478);AG-1478;AG1478HCl;NSC 693255;AG-1478, >98%;AG-1478 AG1478;AG-1478 (NSC-693255);-1478 (Tyrphostin Ag;AG 1478 HYDROCHLORIDE;AG-1478 (Tyrphostin AG-1478)
CBNumber
CB4728982
Molecular Formula
C16H14ClN3O2
Formula Weight
315.75
MOL File
153436-53-4.mol
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AG 1478 HYDROCHLORIDE Property

Melting point:
247 °C(dec.)
Boiling point:
458.5±45.0 °C(Predicted)
Density 
1.337
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming
pka
5.54±0.30(Predicted)
form 
White to light yellow solid.
color 
Light orange to Yellow to Green
λmax
332nm(lit.)
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Safety

RTECS 
VA0953000
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2944
Product name
Tyrphostin AG 1478
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$464
Updated
2024/03/01
Cayman Chemical
Product number
10010244
Product name
AG 1478
Purity
≥98%
Packaging
1mg
Price
$22
Updated
2024/03/01
Cayman Chemical
Product number
10010244
Product name
AG 1478
Purity
≥98%
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
10010244
Product name
AG 1478
Purity
≥98%
Packaging
10mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
10010244
Product name
AG 1478
Purity
≥98%
Packaging
25mg
Price
$363
Updated
2024/03/01
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AG 1478 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Uses

AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

Biological Activity

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).

target

EGFR

AG 1478 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 1478 HYDROCHLORIDE Suppliers

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View Lastest Price from AG 1478 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
AG 1478 HYDROCHLORIDE 153436-53-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

153436-53-4, AG 1478 HYDROCHLORIDERelated Search:

Neratinib Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804) AZD-9291 Nintedanib MK-2206 2HCl WORTMANNIN PD 98059 LY 294002 HYDROCHLORIDE Olaparib AG 1478 Gefitinib Gefitinib O-Methyl-D3 AG 1478 HYDROCHLORIDE N-(3-CHLORO-2-METHYLPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE (3-CHLORO-4-FLUORO-PHENYL)-(6,7-DIMETHOXY-QUINAZOLIN-4-YL)-AMINE N-(3,4-DICHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE

  • N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE
  • 4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL
  • 4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
  • AG-1478
  • AG 1478 HYDROCHLORIDE
  • Tyrphostin AG 1478, free base >99%
  • NSC 693255
  • (3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine
  • AG1478HCl
  • AG-1478 (Tyrphostin AG-1478)
  • AG-1478 (NSC-693255)
  • AG-1478, 97.5%, a selective EGFR inhibitor
  • AG1478; TYRPHOSTIN AG1478; AG 1478; NSC 693255
  • AG1478; TYRPHOSTIN AG1478; AG 1478
  • AG-1478, >98%
  • -1478 (Tyrphostin Ag
  • -1478)
  • AG 1478 HYDROCHLORIDE USP/EP/BP
  • AG-1478 AG1478
  • AG-1478 hydrochloride/Tyrphostin AG 1478
  • 153436-53-4
  • C16H14ClN3O2HCl
  • Inhibitors
  • API
  • Inhibitor