7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
- Product Name
- 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
- CAS No.
- 204452-91-5
- Chemical Name
- 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
- Synonyms
- EOS-61216;7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]PHTHYRIDINE;7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE;1,8-Naphthyridine, 7-(dimethoxymethyl)-1,2,3,4-tetrahydro-
- CBNumber
- CB4731401
- Molecular Formula
- C11H16N2O2
- Formula Weight
- 208.26
- MOL File
- 204452-91-5.mol
7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Property
- Melting point:
- 95°C
- Boiling point:
- 362.5±42.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 10.72±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
- InChIKey
- KKTPPUNNCIHOFA-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000835
- Product name
- 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- D496193
- Product name
- 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- D496193
- Product name
- 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 018159
- Product name
- 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
- Packaging
- 500mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- CHM0028008
- Product name
- 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $712.64
- Updated
- 2021/12/16
7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production
Synthesis
204452-90-4
204452-91-5
General procedure for the synthesis of 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine from [1,8]naphthyridine-2-carboxaldehyde dimethanol: A solution of [1,8]naphthyridine-2-carboxaldehyde dimethanol (20.0 g, 97.9 mmol) in ethanol (400 mL) was hydrogenated catalytically by PtO2 (778 mg) in a hydrogen atmosphere at room temperature and at 1 atmosphere pressure for 18 hours. Upon completion of the reaction, the reaction mixture was filtered through Solka Floc and washed with ethanol-water (1:2, v/v) mixture. The filtrate and washings were combined and concentrated under reduced pressure to remove ethanol. During concentration, the product gradually crystallized. The crystals were collected by filtration and dried under reduced pressure to afford 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine (18.7 g, 92% yield) with a melting point of 91-92.5 °C.1H NMR (300 MHz, CDCl3): δ 7.08 (d, J = 7.4 Hz, 1H), 6.62 (d, J = 7.4 Hz, 1H), 5.07 ( s, 2H; 1H exchangeable with D2O), 3.37-3.29 (m, 2H), 3.29 (s, 6H), 2.64 (t, J = 6.3 Hz, 2H), 1.86-1.78 (m, 2H).13C NMR (75.5 MHz, CDCl3): δ 155.9, 153.0, 136.3, 116.0, 109.8 , 103.9, 53.3, 41.5, 26.6, 21.2.
References
[1] The Journal of organic chemistry, 2004, vol. 69, # 6, p. 1959 - 1966
[2] Patent: WO2016/154369, 2016, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/269225, 2008, A1. Location in patent: Page/Page column 37-38
[4] Patent: US2003/229079, 2003, A1. Location in patent: Page 36
[5] Patent: WO2007/79214, 2007, A2. Location in patent: Page/Page column 102
7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE manufacturers
- Product
- 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE 204452-91-5
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12