3-AMINO-ISONICOTINIC ACID ETHYL ESTER

Product Name: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
CAS No.: 14208-83-4
Chemical Name: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
Synonyms: 3-amino-4-pyridinecarboxyL;Ethyl3-Aminoisonicotinate>3-Amino-isonicotinic acid ethyl;ethyl 3-aMinopyridin-4-carboxylate;Ethyl3-amino-4-pyridinecarboxylate;ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-AMINO-ISONICOTINIC ACID ETHYL ESTER;Ethyl 3-aminoisopyridin-3-carboxylate;3-Amino-isonicotinic acid ethyl ester ,98%;Ethyl 3-aminoisonicotinate, CAS 14208-83-4
CBNumber: CB4733551
Molecular Formula: C8H10N2O2
Formula Weight: 166.18
MOL File: 14208-83-4.mol

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3-AMINO-ISONICOTINIC ACID ETHYL ESTER Property

Melting point:: 170-175
Boiling point:: 304.0±22.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.13±0.18(Predicted)
color: Light orange to Yellow to Green
CAS DataBase Reference: 14208-83-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-45
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1137
Product name: Ethyl 3-Aminoisonicotinate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: E1137
Product name: Ethyl 3-Aminoisonicotinate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $152
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK142958
Product name: 3-Aminoisonicotinicacidethylester
Packaging: 1g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA51047
Product name: 3-Amino isonicotinic acid ethyl ester
Packaging: 5G
Price: $353.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA51047
Product name: 3-Amino isonicotinic acid ethyl ester
Packaging: 10g
Price: $565.6
Updated: 2021/12/16

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3-AMINO-ISONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-white powder or chunks solid

Uses

3-Amino-isonicotinic Acid Ethyl Ester acts as a reagent for the synthetic preparation of heteroaryl compounds as PDE-10 inhibitors useful in treatment and prevention of CNS, metabolic and other diseases. Also in the design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

Synthesis

64-17-5

7579-20-6

14208-83-4

To ethanol (20 mL) was added 3-aminoisonicotinic acid (1.4 g, 10 mmol) and stirred until completely dissolved. Concentrated sulfuric acid (2.94 g, 30 mmol) was added slowly and the reaction was heated to reflux for 20 hours. After completion of the reaction, ethanol was removed by distillation under reduced pressure. To the residue, water was added and the pH was adjusted to 8-9 with 2 N sodium hydroxide solution under cooling in an ice bath. the precipitated solid was filtered and dried to give ethyl 3-aminoisonicotinate (0.70 g, 42% yield). The filtrate was extracted with ethyl acetate, the organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give additional ethyl 3-aminoisonicotinate (0.30 g, 18% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 1.30 (3H, t, J = 7.1 Hz), 4.28 (2H, q, J = 7.1 Hz), 6.66 (2H, br.s), 7.45 (1H, d, J = 5.2 Hz), 7.73 (1H, d, J = 5.2 Hz), 8.23 (1H, s).

References

[1] Australian Journal of Chemistry, 1993, vol. 46, # 7, p. 987 - 993
[2] Patent: EP1844768, 2007, A1. Location in patent: Page/Page column 29-30
[3] Journal of Organic Chemistry, 1952, vol. 17, p. 547,553
[4] Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688

3-AMINO-ISONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride tert-Butyl methyl ether Acetamide Chloroform 3,4-Pyridinedicarboxylic acid Bromine Acetic acid Methanol Sodium hydroxide Magnesium sulfate Thionyl chloride Sodium carbonate

Preparation Products

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3-AMINO-ISONICOTINIC ACID ETHYL ESTER Suppliers

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View Lastest Price from 3-AMINO-ISONICOTINIC ACID ETHYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER 14208-83-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Honest Joy Holdings Limited

Product: 3-Amino-isonicotinic acid ethyl ester 14208-83-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER 14208-83-4
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-23

14208-83-4, 3-AMINO-ISONICOTINIC ACID ETHYL ESTERRelated Search:

3-AMINO-ISONICOTINIC ACID METHYL ESTER 3-Aminoisonicotinic acid hydrate (1:1) Ethyl nicotinate Ethyl isonicotinate Ethyl 5-aminopyridine-3-carboxylate ,97% Ethyl 6-aminonicotinate Ethyl 2-Aminoisonicotinate RARECHEM AL BW 1166 ethyl 3-amino-5-cyano-2-methylpyridine-4-carboxylate ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 3-AMINO-ISONICOTINIC ACID ETHYL ESTER 3-Amino-2-methoxy-6-methyl-4-pyridinecarboxylicacidethylester 3-AMINO-ISONICOTINIC ACID ETHYL ESTER HCL 3-AMINO-ISONICOTINIC ACID ETHYL ESTER DIHYDROCHLORIDE

Ethyl3-amino-4-pyridinecarboxylate

3-Amino-isonicotinic acid ethyl ester ,98%

Isonicotinic acid, 3-amino-, ethyl ester (8CI)

Ethyl 3-aminopyridine-4-carboxylate, 4-(Ethoxycarbonyl)pyridin-3-amine

ethyl 3-aMinopyridin-4-carboxylate

ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE

3-AMINOPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER

3-AMINO-ISONICOTINIC ACID ETHYL ESTER

3-AMINO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER

3-Amino-isonicotinic acid ethyl

Ethyl3-Aminoisonicotinate&gt

3-amino-4-pyridinecarboxyL

4-Pyridinecarboxylic acid, 3-amino-, ethyl ester

3-AMINO-ISONICOTINIC ACID ETHYL ESTER ISO 9001：2015 REACH

4-Pyridinecarboxylic acid, 3-amino-, ethyl ester (9CI, ACI)

3-amino-4-Pyridinecarboxylic acid ethyl ester (9CI ACI)

Ethyl 3-aminoisonicotinate, CAS 14208-83-4

Ethyl 3-aminoisopyridin-3-carboxylate

14208-83-4

Heterocycle-Pyridine series

Pyridine

pharmacetical

Esters

Pyridines

API intermediates

Pyrazoles