2-(Methanesulfonyl)phenylboronic acid
Application- Product Name
- 2-(Methanesulfonyl)phenylboronic acid
- CAS No.
- 330804-03-0
- Chemical Name
- 2-(Methanesulfonyl)phenylboronic acid
- Synonyms
- 2-(METHYLSULFONYL)PHENYLBORONIC ACID;2-Boronophenyl methyl sulphone;2-Methylsulfonylphenylboronicaci;2-(Methanesulfonyl)phenylboronic acid;2-(METHYLSULPHONYL)BENZENEBORONIC ACID;3-(Methanesulphonyl)phenylboronic acid;B-[2-(Methylsulfonyl)phenyl]boronic acid;2-(Methylsulphonyl)benzeneboronic acid 98%;2-(Methylsulfonyl)benzeneboronic acid, 98%;Boronic acid, B-[2-(methylsulfonyl)phenyl]-
- CBNumber
- CB4733612
- Molecular Formula
- C7H9BO4S
- Formula Weight
- 200.02
- MOL File
- 330804-03-0.mol
2-(Methanesulfonyl)phenylboronic acid Property
- Melting point:
- 78-84°C
- Boiling point:
- 469.2±51.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.90±0.53(Predicted)
- form
- solid
- color
- White
- InChI
- 1S/C7H9BO4S/c1-13(11,12)7-5-3-2-4-6(7)8(9)10/h2-5,9-10H,1H3
- InChIKey
- MSQFFCRGQPVQRS-UHFFFAOYSA-N
- SMILES
- CS(=O)(=O)c1ccccc1B(O)O
- CAS DataBase Reference
- 330804-03-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36
- Safety Statements
- 22-24/25-26
- WGK Germany
- WGK 3
- Hazard Note
- Irritant
- HS Code
- 2931900090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CDS004929
- Product name
- 2-(Methylsulfonyl)phenylboronic acid
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- M2678
- Product name
- 2-(Methylsulfonyl)phenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- M339145
- Product name
- 2-(Methylsulfonyl)phenylboronicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 6660-1-Y3
- Product name
- 2-(Methylsulfonyl)benzeneboronic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 069087
- Product name
- 2-(Methylsulfonyl)phenylboronic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $851
- Updated
- 2021/12/16
2-(Methanesulfonyl)phenylboronic acid Chemical Properties,Usage,Production
Application
2-Methylsulfonylphenylboronic acid is an important organic synthesis intermediate that can be used to synthesize polyolefins, styrene and biphenyl derivatives through the Suzuki aryl coupling reaction, thus finding applications in the synthesis of numerous natural products and organic materials.
Synthesis
To the salt kettle add water 1800kg, sulfonesulfonyl chloride 700kg, sodium bicarbonate 450kg and sodium sulfite 330kg, salt reaction at atmospheric pressure, reaction temperature of 60 ??, holding time of 4 hours, carbon dioxide gas produced by the reaction and a small amount of water evacuation, to be the reaction is complete, while the heat is 40-50 ?? filtration, the mother liquor is pumped by vacuum into the methylation kettle, the filtration residue is separate. The slag was treated separately. The mother liquor is further heated to 70?? in the methylation kettle, and then 158kg of monochloromethane gas is passed under the pressure of 0.5kg/cm3, and the crystallization is cooled by heat preservation. When the crystallization mother liquor cooled to 40 ??, discharge filtration, filter cake and then centrifuge centrifugation, filtration mother liquor and centrifugation mother liquor centralized distillation, water vapor condensation through the condenser condensation set, resulting in a separate treatment of waste salt. After the wet product is dried by the drier, methylsulfonylbenzene is obtained. The content of methylsulfonylbenzene is above 99%, and the yield is about 70%. Methylsulfonylbenzene is brominated to obtain o-bromo methylsulfonylbenzene.
The reaction flask was charged with 0.05 mol (0.1eq) of o-bromomethylsulfonylbenzene, 0.55 mol (1.1eq) of magnesium flakes, a few particles of monomers of iodine, and 300 ml of THF, stirred, warmed up to reflux, and triggered by Gram's initiation, and the addition of m-bromotoluene, 0.45 mol (0.9eq) was continued dropwise in the refluxed state. Dropping finished reflux holding reaction, the reaction time to, lower the temperature to -60.0 ??, began to drop the addition of trimethyl borate 1.0mol (2.0eq), dropping finished, holding reaction until the raw material reaction is complete, raise the temperature, add water, drop hydrochloric acid hydrolysis, adjust the pH to 1-2, hold the reaction time to, reaction time to, rotary evaporation, pumping dry, pulping and purification, drying to obtain a white solid 2-methylsulfonylphenylboronic acid 0.44 mol, moisture 0.05%, purity 98.64%, yield 88.0%.
2-(Methanesulfonyl)phenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Methanesulfonyl)phenylboronic acid manufacturers
- Product
- 2-(Methanesulfonyl)phenylboronic acid 330804-03-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12