6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID

Product Name: 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID
CAS No.: 231958-14-8
Chemical Name: 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID
Synonyms: 6-Aminonicotinic acid, 6-BOC protected;6-Aminonicotinic acid, N-BOC protected;6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID;6-{[(tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid;6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-;6-[(tert-Butoxycarbonyl)amino]pyridine-3-carboxylic acid, 2-[(tert-Butoxycarbonyl)amino]-5-carboxypyridine
CBNumber: CB4736037
Molecular Formula: C11H14N2O4
Formula Weight: 238.24
MOL File: Mol file

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6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID Property

Melting point:: 292-296°C
Boiling point:: 356.5±27.0 °C(Predicted)
Density: 1.293±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: Solid
pka: 12.92±0.70(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 044341
Product name: 6-[(tert-Butoxycarbonyl)amino]nicotinic acid
Purity: 95+%
Packaging: 250mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-Z1
Product name: 6-Aminonicotinic acid, 6-Boc protected
Packaging: 250mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 1520AB
Product name: 6-((tert-Butoxycarbonyl)amino)nicotinicacid
Packaging: 250mg
Price: $151
Updated: 2021/12/16

Matrix Scientific

Product number: 044341
Product name: 6-[(tert-Butoxycarbonyl)amino]nicotinic acid
Purity: 95+%
Packaging: 1g
Price: $188
Updated: 2021/12/16

AK Scientific

Product number: 1520AB
Product name: 6-((tert-Butoxycarbonyl)amino)nicotinicacid
Packaging: 1g
Price: $303
Updated: 2021/12/16

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6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID Chemical Properties,Usage,Production

Synthesis

144186-11-8

231958-14-8

Step 5. Synthesis of 6-((tert-butoxycarbonyl)amino)nicotinic acid. Methyl 6-((tert-butoxycarbonyl)amino)nicotinate (50 g, 19 mmol) was dissolved in methanol (50 mL) and 1N NaOH aqueous solution (40 mL, 40 mmol) was added. The reaction mixture was stirred at room temperature for 20 hours, followed by heating to 60°C for 2 hours. After completion of the reaction, the solution was cooled and methanol was removed under vacuum. To the remaining solution, 3N HCl was slowly added and the pH was adjusted to 3. A white solid precipitate was precipitated. The solid product was collected by filtration, washed with water and dried to give 6-((tert-butoxycarbonyl)amino)nicotinic acid 23 g (89% yield) as a white solid.

References

[1] Patent: WO2010/130708, 2010, A1. Location in patent: Page/Page column 72
[2] Patent: WO2010/144345, 2010, A1. Location in patent: Page/Page column 65
[3] Patent: WO2016/33445, 2016, A1. Location in patent: Paragraph 0297
[4] Patent: WO2009/36996, 2009, A2. Location in patent: Page/Page column 92
[5] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0233

6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID Suppliers

China 29 Germany 1 India 1 United Kingdom 2 United States 5 Global 38

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231958-14-8, 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACIDRelated Search:

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6-Aminonicotinic acid, N-BOC protected

6-[(tert-Butoxycarbonyl)amino]pyridine-3-carboxylic acid, 2-[(tert-Butoxycarbonyl)amino]-5-carboxypyridine

6-Aminonicotinic acid, 6-BOC protected

3-Pyridinecarboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-

6-{[(tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid

6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylic acid

231958-14-8