ChemicalBook > CAS DataBase List > 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE

Product Name
3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
CAS No.
10010-93-2
Chemical Name
3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
Synonyms
AKOS B014453;AKOS PAO-1253;AKOS PAO-1201;BUTTPARK 76\07-66;BUTTPARK 29\08-72;AKOS BBS-00002817;CBI-BB ZERO/006128;ART-CHEM-BB B014453;TIMTEC-BB SBB004075;3-TRIFLUOROMETHYL-5-(METHYL)PYRAZOLE
CBNumber
CB4737458
Molecular Formula
C5H5F3N2
Formula Weight
150.1
MOL File
10010-93-2.mol
More
Less

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE Property

Melting point:
88-90 °C(lit.)
Boiling point:
187℃
Density 
1.355
Flash point:
67℃
storage temp. 
Inert atmosphere,Room Temperature
pka
11.12±0.10(Predicted)
form 
Powder
color 
White
InChI
InChI=1S/C5H5F3N2/c1-3-2-4(10-9-3)5(6,7)8/h2H,1H3,(H,9,10)
InChIKey
DLCHCAYDSKIFIN-UHFFFAOYSA-N
SMILES
N1C(C(F)(F)F)=CC(C)=N1
CAS DataBase Reference
10010-93-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2032
Product name
3-Methyl-5-(trifluoromethyl)pyrazole
Purity
>98.0%(GC)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
M2032
Product name
3-Methyl-5-(trifluoromethyl)pyrazole
Purity
>98.0%(GC)
Packaging
5g
Price
$122
Updated
2025/07/31
TRC
Product number
M330600
Product name
3-Methyl-5-(trifluoromethyl)pyrazole
Packaging
1g
Price
$50
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK258365
Product name
3-Methyl-5-trifluoromethyl-1H-pyrazole
Purity
97%
Packaging
1g
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-3-35
Product name
3-Methyl-5-(trifluoromethyl)pyrazole
Purity
97%
Packaging
1g
Price
$16
Updated
2021/12/16
More
Less

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to orange solid

Uses

3-Methyl-5-(trifluoromethyl)pyrazole is a reagent used in the preparation of (fluoromethyl)pyrazole via microwave-assisted Stille coupling.

Definition

ChEBI: 3-Methyl-5-(trifluoromethyl)-1H-pyrazole is a member of pyrazoles.

General Description

3-Methyl-5-(trifluoromethyl)pyrazole is a pyrazole derivative. It has been reported to be synthesized from 3-methyl-5-trifluoromethyl-1H-pyrazole.

Synthesis

367-57-7

10010-93-2

Example 127: Preparation of 5-methyl-3-trifluoromethyl-1H-pyrazole Hydrazine hydrate (945 μl, 30 mmol) was slowly added to a solution of 1,1,1-trifluoro-2,4-pentanedione (4.62 g, 30 mmol) in methanol (20 ml) at 0 °C. The reaction mixture was gradually warmed up to room temperature and stirred at that temperature for 16 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give 5-methyl-3-trifluoromethyl-1H-pyrazole as a yellow solid (4.5 g, 95% yield). 1H-NMR (400 MHz, CDCl3): δ 2.35 (s, 3H, CH3), 6.32 (s, 1H, CH), 9.88 (bs, 1H, NH) ppm.

References

[1] Patent: WO2007/71900, 2007, A1. Location in patent: Page/Page column 88-89
[2] Tetrahedron Letters, 2016, vol. 57, # 14, p. 1555 - 1559
[3] Tetrahedron Letters, 2014, vol. 55, # 52, p. 7198 - 7202
[4] Patent: WO2013/6792, 2013, A1. Location in patent: Paragraph 0149
[5] Journal of the American Chemical Society, 1998, vol. 120, # 44, p. 11408 - 11418

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution 1,1,1-Trifluoro-2,4-pentanedione

Preparation Products

More
Less

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE Suppliers

Americas 1 China 188 Europe 1 Germany 5 India 10 Japan 1 Russia 3 Switzerland 2 United Kingdom 10 United States 28 Global 249
Shanghai Baisley Pharmaceutical Technology Co., Ltd.
Tel
021-15995002467 15995002467
Email
chen_shuming@126.com
Country
China
ProdList
148
Advantage
58
Haimen DsHare Pharmaceutical Technology Co., Ltd.
Tel
+86-0513-68050135 13962878782
Fax
0513-68050130
Email
zhuwdsh@126.com
Country
China
ProdList
158
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Dancheng Huatai Biotechnology Co., Ltd.
Tel
13482210809 13482210809
Email
hli@3wpharm.com
Country
China
ProdList
334
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Carbott PharmTech Inc.
Tel
0535-6385396
Fax
+86 (535) 638-9971
Email
info@carbottpharm.com
Country
China
ProdList
957
Advantage
56
More
Less

View Lastest Price from 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-methyl-3-(trifluoromethyl)pyrazole 10010-93-2
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2025-06-13
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 10010-93-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 10010-93-2
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-06

10010-93-2, 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLERelated Search:

4-BROMO-3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE 2-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL]-THIOPHENE-5-CARBOXYLIC ACID 2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-SULFONYL CHLORIDE 2-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL]-THIOPHENE-5-CARBOXALDEHYDE 5-HYDROXY-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE 3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole97%,3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole 97%,3-HYDROXY-1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 3-(4-BROMO-5-METHYL-3-TRIFLUOROMETHYL-PYRAZOL-1-YL)-PROPIONIC ACID 5-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-5-YL]-THIOPHENE-2-SULFONYL CHLORIDE 4-BROMO-5-METHYL-3-TRIFLUOROMETHYLPYRAZOLE 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONYL CHLORIDE 4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE,5-Chloro-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxyaldehyde ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE,Ethyl 1-methyl-3-(trifluoromethyl)pyrazole-4- 1-ACETYL-3(5)-(NONAFLUORO-1-BUTYL)-5(3)-(TRIFLUOROMETHYL)PYRAZOLE 5-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL]-THIOPHENE-2-SULFONAMIDE 1-ACETYL-4-CHLORO-3(5)-TRIFLUOROMETHYL-5(3)-(PHENYL)PYRAZOLE 1-ACETYL-3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE 1-ACETYL-4-BROMO-3(5)-TRIFLUOROMETHYL-5(3)-(METHYL)PYRAZOLE

  • TIMTEC-BB SBB004075
  • 1H-Pyrazole,3-methyl-5-(trifluoromethyl)-
  • CBI-BB ZERO/006128
  • BUTTPARK 29\08-72
  • BUTTPARK 76\07-66
  • ART-CHEM-BB B014453
  • 3-TRIFLUOROMETHYL-5-(METHYL)PYRAZOLE
  • 3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE
  • 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
  • 5-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE
  • AKOS B014453
  • AKOS BBS-00002817
  • AKOS PAO-1253
  • AKOS PAO-1201
  • Pyrazole, 3(or 5)-methyl-5(or 3)-(trifluoromethyl)-
  • Pyrazole, 3-methyl-5-(trifluoromethyl)-
  • 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 99%
  • 3-Methyl-5-trifluoromethyl-1H-pyrazole ,97%
  • 3-methyl-5-(trifluoromethyl)-1H-pyrazole(SALTDATA: FREE)
  • 5(3)-Methyl-3(5)-(trifluoroMethyl)pyrazole
  • 5-(trifluoromethyl)-3-methyl-1H-pyrazole
  • 3-Methyl-5-(trifluoromethyl)pyrazole&gt
  • TIANFU-CHEM 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
  • 3-Methyl-5-(trifluoromethyl)pyrazole, 99%
  • 10010-93-2
  • Pyrazoles
  • Pyrazole series
  • Heterocyclic Compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrazoles
  • blocks
  • FluoroCompounds
  • Heterocycles