3-HYDROXY-1-N-CBZ-PYRROLIDINE

Product Name: 3-HYDROXY-1-N-CBZ-PYRROLIDINE
CAS No.: 95656-88-5
Chemical Name: 3-HYDROXY-1-N-CBZ-PYRROLIDINE
Synonyms: N-CBZ-3;3-HYDROXY-1-N-CBZ-PY;N-Cbz-3-pyrrolidinol;1-Cbz-3-hydroxypyrrolidine;N-CBZ-3-HYDROXYPYRROLIDINE;3-HYDROXY-1-N-CBZ-PYRROLIDINE;Benzyl 3-hydroxy-1-pyrrolidinecarboxylate;BENZYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-Pyrrolidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester
CBNumber: CB4738521
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 95656-88-5.mol

More

Less

3-HYDROXY-1-N-CBZ-PYRROLIDINE Property

Boiling point:: 370.7±42.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.72±0.20(Predicted)
Appearance: White to light yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B535218
Product name: Benzyl3-Hydroxypyrrolidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-177
Product name: 1-Cbz-3-hydroxypyrrolidine
Packaging: 1g
Price: $35
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-177
Product name: 1-Cbz-3-hydroxypyrrolidine
Packaging: 5G
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W9762
Product name: N-Cbz-3-Hydroxypyrrolidine
Packaging: 1g
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-177
Product name: 1-Cbz-3-hydroxypyrrolidine
Packaging: 25g
Price: $150
Updated: 2021/12/16

More

Less

3-HYDROXY-1-N-CBZ-PYRROLIDINE Chemical Properties,Usage,Production

Uses

Benzyl 3-Hydroxypyrrolidine-1-carboxylate (cas# 95656-88-5) is a useful research chemical. It is used in the preparation of sulfonyl substituted (hetero) aromatic derivatives as ROR-γ inhibitors for treatment of autoimmune diseases.

Synthesis

40499-83-0

501-53-1

95656-88-5

To a solution of pyrrolidin-3-ol (10.45 g, 120.1 mmol) in dichloromethane (300 mL) were sequentially added benzyl chloroformate (24.6 g, 144 mmol) and triethylamine (24.3 g, 240.2 mmol). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved in ethyl acetate (100 mL) and extracted with deionized water (60 mL). The organic layer was separated and washed sequentially with deionized water (60 mL) and saturated aqueous sodium chloride solution (60 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 2:1, v/v) to afford N-CBZ-3-hydroxypyrrolidine (15.2 g, 57% yield) as a colorless gel. LC-MS (ESI): m/z = 222.1 [M + H]+.

References

[1] Chemical Communications, 2007, # 21, p. 2136 - 2138
[2] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 581
[3] Patent: WO2007/60526, 2007, A1. Location in patent: Page/Page column 44; 71
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 12, p. 2818 - 2841
[5] Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 1, p. 207 - 215

3-HYDROXY-1-N-CBZ-PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-HYDROXY-1-N-CBZ-PYRROLIDINE Suppliers

Canada 1 China 86 India 2 United Kingdom 1 United States 16 Global 106

Sichuan Guanghan Bio-Tech Co., Ltd

Tel: +86-28-86127071
Fax: +86-28-86127072
Email: info@sino-produce.com
Country: China
ProdList: 406
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Chongqing Werlchem Fine Chemical Co.Ltd.

Tel: 023-67521957 13320292971
Fax: 86-23-67511575
Email: sales@werlchem.com
Country: China
ProdList: 26
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

More

Less

View Lastest Price from 3-HYDROXY-1-N-CBZ-PYRROLIDINE manufacturers

Career Henan Chemical Co

Product: 3-HYDROXY-1-N-CBZ-PYRROLIDINE 95656-88-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-08

95656-88-5, 3-HYDROXY-1-N-CBZ-PYRROLIDINERelated Search:

N-Cbz-Hydroxy-L-proline Z-HYP-OME 3-HYDROXY-1-N-CBZ-PYRROLIDINE 3-CARBOXYMETHOXY-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER (R)-1-CBZ-3-PYRROLIDINOL (S)-1-CBZ-3-PYRROLIDINOL 95 Z-TRANS-4-HYDROXY-L-PROLINOL 3-Pyrrolidinol Z-HYP(TBU)-OH (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 4-BENZYLOXY-2-PYRROLIDIN-1-YLMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER Z-CIS-HYP-OH 1-N-CBZ-4-HYDROXY-BETA-PROLINE (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE Z-D-CIS-HYP-OH AKOS 334 AKOS 91841 ANTI-N-CBZ-7-HYDROXY-2-AZABICYCLO[2.2.1]HEPTANE

1-Pyrrolidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester

BENZYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE

3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER

N-CBZ-3-HYDROXYPYRROLIDINE

3-HYDROXY-1-N-CBZ-PYRROLIDINE

N-Cbz-3-pyrrolidinol

3-HYDROXY-1-N-CBZ-PY

N-CBZ-3

1-Cbz-3-hydroxypyrrolidine

Benzyl 3-hydroxy-1-pyrrolidinecarboxylate

95656-88-5

Alcohols and Derivatives