(R)-1-CBZ-3-PYRROLIDINOL

Product Name: (R)-1-CBZ-3-PYRROLIDINOL
CAS No.: 100858-33-1
Chemical Name: (R)-1-CBZ-3-PYRROLIDINOL
Synonyms: (R)-(-)-1-Cbz-3-pyrroL;(R)-1-Cbzl-3-pyrrolidinol;(3R)-N-CBZ-3-pyrrolidinol;(R)-(-)-1-Cbz-3-pyrrolidinol;(R)-N-Cbz-3-hydroxypyrroline;N-Cbz-3(R)-hydroxypyrrolidine;R-1-N-CBZ-3- hydroxy-pyrroline;(R)-N-Cbz-3-hydroxypyrrolidine;(R)-1-Cbz-3-pyrrolidinol, ee: 98%;(R)-(?)-1-Cbz-3-pyrrolidinol
CBNumber: CB0505444
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 100858-33-1.mol

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(R)-1-CBZ-3-PYRROLIDINOL Property

Melting point:: 74-79 °C
Boiling point:: 370.7±42.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Chloroform
form: powder to crystal
pka: 14.72±0.20(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C12H15NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11,14H,6-9H2/t11-/m1/s1
InChIKey: MBLJFGOKYTZKMH-LLVKDONJSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CC[C@@H](O)C1
CAS DataBase Reference: 100858-33-1

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654655
Product name: (R)-(?)-1-Cbz-3-pyrrolidinol
Purity: 95%
Packaging: 5g
Price: $345
Updated: 2025/07/31

Sigma-Aldrich

Product number: 654655
Product name: (R)-(?)-1-Cbz-3-pyrrolidinol
Purity: 95%
Packaging: 1g
Price: $75.1
Updated: 2023/06/20

TCI Chemical

Product number: C2585
Product name: (R)-1-Carbobenzoxy-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: C2585
Product name: (R)-1-Carbobenzoxy-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $194
Updated: 2025/07/31

TRC

Product number: C227808
Product name: (R)-(-)-1-Cbz-3-pyrrolidinol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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(R)-1-CBZ-3-PYRROLIDINOL Chemical Properties,Usage,Production

Chemical Properties

White to brown crystal to powder

Uses

(R)-1-CBZ-3-PYRROLIDINOL is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.

Synthesis

130312-02-6

100858-33-1

General procedure for the synthesis of N-CBZ-3-(R)-hydroxypyrrolidine using N-Cbz-3-pyrrolidone as starting material: a reaction mixture of 1 mL of potassium phosphate buffer (100 mM, pH 7.0) containing 200 mM of substrate, 1 mM NAD+, 5% (v/v) 2-propanol, and 10 mg of crude enzyme READH was warmed at 50 °C. For ChKRED20, the reaction conditions were adjusted to 40% (v/v) 2-propanol and 40°C reaction temperature. The reaction progress was monitored by thin layer chromatography (TLC) and the reaction was terminated by the addition of 1 mL of methyl tert-butyl ether extraction. The organic phase was dried with anhydrous sodium sulfate and concentrated. The conversion and enantiomeric excess were determined by chiral high performance liquid chromatography (HPLC). The products were purified by silica gel column chromatography and structurally characterized by nuclear magnetic resonance (NMR) analysis, spinometry and mass spectrometry (MS).

References

[1] Process Biochemistry, 2017, vol. 56, p. 90 - 97

(R)-1-CBZ-3-PYRROLIDINOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-CBZ-3-PYRROLIDINOL Suppliers

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View Lastest Price from (R)-1-CBZ-3-PYRROLIDINOL manufacturers

Career Henan Chemical Co

Product: (R)-1-CBZ-3-PYRROLIDINOL 100858-33-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-18

100858-33-1, (R)-1-CBZ-3-PYRROLIDINOLRelated Search:

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(R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE

(R)-benzyl 3-hydroxypyrrolidine-1-carboxylate

(R)-N-Cbz-3-hydroxypyrrolidine

(R)-3-Hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

N-Cbz-3(R)-hydroxypyrrolidine

(R)-1-Benzyloxycarbonyl-3-pyrrolidinol, (R)-1-Carbobenzoxy-3-pyrrolidinol, (R)-N-Z-3-Pyrrolidinol

(R)-1-Cbzl-3-pyrrolidinol

R-1-N-CBZ-3- hydroxy-pyrroline

(R)-(-)-1-Cbz-3-pyrrolidinol

(3R)-N-CBZ-3-pyrrolidinol

(R)-1-Cbz-3-pyrrolidinol, ee: 98%

(R)-1-Carbobenzoxy-3-hydroxypyrrolidine (R)-1-Cbz-3-pyrrolidinol

benzyl (3R)-3-hydroxypyrrolidine-1-carboxylate

(R)-N-Cbz-3-hydroxypyrroline

(S)-N-Boc-3-hydroxypyrroline,99%e.e.

(R)-1-Cbz-3-pyrrolidinol, 98%, ee: 98%

Benzyl (R)-3-hydroxypyrrolidine-1-carboxylate

(R)-1-Carbobenzoxy-3-pyrrolidinol &gt

(R)-(-)-1-Cbz-3-pyrroL

1-Pyrrolidinecarboxylic acid, 3-hydroxy-, phenylmethyl ester, (3R)-

(R)-1-Benzyloxycarbonyl-3-hydroxypyrrolidine

(R)-1-Carbobenzoxy-3-hydroxypyrrolidine

(R)-(3-hydroxypyrrolidin-1-yl)(phenyl)methanone

(<i>R</i>)-(?)-1-Cbz-3-pyrrolidinol

100858-33-1

100856-33-1