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N-Cbz-Nortropinone

Product Name
N-Cbz-Nortropinone
CAS No.
130753-13-8
Chemical Name
N-Cbz-Nortropinone
Synonyms
N-Cbz-tropine;N-Cbz-Notropinone;N-CBZ-NORTROPINONE;N-Cbz-4-Nortropinone;N-Cbz-nortropinone ,97%;8-Cbz-3-oxo-8-azabicyclo[3.2.1]octane;Benzyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;benzyl (1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;(1S)-BENZYL 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE;Benzyl (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
CBNumber
CB6171135
Molecular Formula
C15H17NO3
Formula Weight
259.3
MOL File
130753-13-8.mol
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N-Cbz-Nortropinone Property

Boiling point:
415.7±45.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-1.70±0.20(Predicted)
color 
white crystalline powder
InChI
InChI=1S/C15H17NO3/c17-14-8-12-6-7-13(9-14)16(12)15(18)19-10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2
InChIKey
RMIQGRJJCNFRRU-UHFFFAOYSA-N
SMILES
C12N(C(OCC3=CC=CC=C3)=O)C(CC1)CC(=O)C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C227945
Product name
N-Cbz-4-Nortropinone
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
C227945
Product name
N-Cbz-4-Nortropinone
Packaging
500mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-S17
Product name
Benzyl (1S)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity
97.0%
Packaging
250mg
Price
$68
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-S17
Product name
Benzyl (1S)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity
97.0%
Packaging
1g
Price
$118
Updated
2021/12/16
Matrix Scientific
Product number
075012
Product name
Benzyl 3-oxo-8-azabicyclo-[3.2.1]octane-8-carboxylate
Purity
95+%
Packaging
5g
Price
$145
Updated
2021/12/16
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N-Cbz-Nortropinone Chemical Properties,Usage,Production

Synthesis

25602-68-0

501-53-1

130753-13-8

1. 8-Azabicyclo[3,2,1]octan-3-one hydrochloride (10.0 g; 71.84 mmol) was dissolved in dichloroethane (DCE, 60 mL), and 1-chloroethyl chloroformate (ACE-C1, 14.5 mL; 19.11 g; 133.7 mmol) was added slowly and dropwise. The reaction mixture was stirred overnight at room temperature, then diluted with ether (Et2O, 400 mL) and filtered. The filtrate was concentrated under reduced pressure to give crude chloroethyl carbamate. 2. The above crude product was dissolved in methanol (MeOH, 200 mL) and stirred at room temperature for 1 h. Subsequently, it was concentrated under reduced pressure at 55 °C to obtain crude desmethyltropinone hydrochloride (brown solid, 11.4 g, 98% yield). 3. The crude product was purified by recrystallization from formonitrile to give a white crystalline solid (5 g, 43% yield).1H NMR (400 MHz, DMSO-d6) δ 1.79 (dd, J = 15.0,6.9 Hz, 2H), 2.09 (m, 2H), 2.40 (d, J = 16.7 Hz, 2H), 3.02 (dd, J = 17.1,4.3 Hz, 2H), 4.23 (s, 2H), 10.00 (br s, 2H). 4. desmethyltropinone (5.10 g; 31.55 mmol) was dissolved in dichloromethane (CH2Cl2, 50 mL) and benzyl chloroformate (4.29 mL; 5.11 g; 29.98 mmol) and diisopropylethylamine (DIPEA, 16.48 mL; 12.23 g; 94.66 mmol) were added slowly and dropwise (note exothermic reaction). The reaction mixture was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). 5. The organic phase was washed with 1N hydrochloric acid (2 x 100 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product (7.2 g, 88% yield).1H NMR (400 MHz, CDCl3) δ 1.71 (dd, J = 15.0,7.2Hz, 2H), 2.12 (m, 2H), 2.38 (d, J = 15.9 Hz, 2H), 2.67 (m, 2H), 4.62 (s, 2H), 5.22 (s, 2H), 7.38 (m, 5H).

References

[1] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 84
[2] Patent: JP2015/124178, 2015, A. Location in patent: Paragraph 0143
[3] Patent: WO2004/100946, 2004, A1. Location in patent: Page 77
[4] Patent: WO2006/58303, 2006, A2. Location in patent: Page/Page column 71
[5] Patent: WO2010/126163, 2010, A1. Location in patent: Page/Page column 38-39

N-Cbz-Nortropinone Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Cbz-Nortropinone Suppliers

China 108 Germany 1 India 1 United Kingdom 1 United States 13 Global 124
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Suzhou Chireach Biomedical Technology Co., Ltd.
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0512-65856968
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0512-65647218
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sales@chireach.com
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China
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Beijing Mediking Biopharm Co., Ltd
Tel
010-81769521,89753524,81760121 15901403431
Fax
+86-10-81769652
Email
sales01@mediking.cn
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China
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
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sales@jingyan-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
Email
isenchem@163.com
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
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021-58099609
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bin.wu@shlschem.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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028-84555506 800101999
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cdhxsj@163.com
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China
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View Lastest Price from N-Cbz-Nortropinone manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
N-Cbz-Nortropinone 130753-13-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Wuhan Xinhao Biotechnology Co., Ltd
Product
N-Cbz-Nortropinone 130753-13-8
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-20
Career Henan Chemical Co
Product
N-Cbz-Nortropinone 130753-13-8
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-22

130753-13-8, N-Cbz-NortropinoneRelated Search:

Tropinone Benzyl isocyanate Benzyl alcohol N-OCTANE Benzyloxyacetyl chloride Benzyl benzoate Benzyl nicotinate Benzyl chloride Trimethoprim RESMETHRIN Nequinate beta-Methyl vinyl phosphate (MAP) TPCK 1-N-PHENYL-PIPERIDIN-4-ONE (R)-1-CBZ-3-PYRROLIDINOL (S)-1-CBZ-3-PYRROLIDINOL 95 Benzyl N-Carbethoxy-4-tropinone

  • N-Cbz-nortropinone ,97%
  • N-Cbz-4-Nortropinone
  • 8-Cbz-3-oxo-8-azabicyclo[3.2.1]octane
  • Benzyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
  • N-Cbz-Notropinone
  • benzyl (1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
  • 8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-oxo-, phenylmethyl ester
  • Benzyl (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
  • (1R)-tert-Butyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
  • N-CBZ-NORTROPINONE
  • N-Cbz-tropine
  • (1S)-BENZYL 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
  • 3-Oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid benzyl ester
  • rac-benzyl (1r,5s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
  • 130753-13-8
  • pharmacetical
  • Heterocycle