1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

Product Name: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
CAS No.: 688348-25-6
Chemical Name: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
Synonyms: PDM 2;PDM-2;PDM2;PDM 2;688348-25-6;(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene;1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-;inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR
CBNumber: CB4739467
Molecular Formula: C14H9Cl3
Formula Weight: 283.58
MOL File: 688348-25-6.mol

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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Property

Boiling point:: 394.2±42.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006342
Product name: PDM 2
Purity: ≥98%
Packaging: 10mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 10006342
Product name: PDM 2
Purity: ≥98%
Packaging: 50mg
Price: $206
Updated: 2024/03/01

Cayman Chemical

Product number: 10006342
Product name: PDM 2
Purity: ≥98%
Packaging: 100mg
Price: $360
Updated: 2024/03/01

ApexBio Technology

Product number: C5219
Product name: PDM2
Packaging: 100mg
Price: $389
Updated: 2021/12/16

AK Scientific

Product number: 1121AH
Product name: 1,3-Dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
Packaging: 100mg
Price: $499
Updated: 2021/12/16

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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Chemical Properties,Usage,Production

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a K_i of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

Uses

PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

References

[1] de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Suppliers

China 65 United States 7 USA 1 Global 73

Dalian Meilun Biotech Co., Ltd.

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688348-25-6, 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENERelated Search:

3(4'-CHLOROPHENYL)-6,8-DICHLORO-4-METHYLCOUMARIN 6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-METHYLCOUMARIN 3,4-DI-(4'-CHLOROPHENYL)-6,8-DICHLOROPHENYL COUMARIN 6,8-DICHLORO-3-(4'-CHLOROPHENYL)-4-PHENYL COUMARIN 6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-PHENYLCOUMARIN 6,8-DICHLORO-3-(4'-CHLOROPHENYL)-4-(4'-HYDROXYPHENYL)COUMARIN 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

PDM 2

1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene

PDM-2;PDM2;PDM 2;688348-25-6

Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-

inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR

(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene

688348-25-6