ChemicalBook > CAS DataBase List > 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

Product Name
1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
CAS No.
688348-25-6
Chemical Name
1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
Synonyms
PDM 2;PDM-2;PDM2;PDM 2;688348-25-6;(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene;1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-;inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR
CBNumber
CB4739467
Molecular Formula
C14H9Cl3
Formula Weight
283.58
MOL File
688348-25-6.mol
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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Property

Boiling point:
394.2±42.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006342
Product name
PDM 2
Purity
≥98%
Packaging
10mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
10006342
Product name
PDM 2
Purity
≥98%
Packaging
50mg
Price
$206
Updated
2024/03/01
Cayman Chemical
Product number
10006342
Product name
PDM 2
Purity
≥98%
Packaging
100mg
Price
$360
Updated
2024/03/01
ApexBio Technology
Product number
C5219
Product name
PDM2
Packaging
100mg
Price
$389
Updated
2021/12/16
AK Scientific
Product number
1121AH
Product name
1,3-Dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
Packaging
100mg
Price
$499
Updated
2021/12/16
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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Chemical Properties,Usage,Production

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

Uses

PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

References

[1] de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Suppliers

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688348-25-6, 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENERelated Search:

3(4'-CHLOROPHENYL)-6,8-DICHLORO-4-METHYLCOUMARIN 6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-METHYLCOUMARIN 3,4-DI-(4'-CHLOROPHENYL)-6,8-DICHLOROPHENYL COUMARIN 6,8-DICHLORO-3-(4'-CHLOROPHENYL)-4-PHENYL COUMARIN 6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-PHENYLCOUMARIN 6,8-DICHLORO-3-(4'-CHLOROPHENYL)-4-(4'-HYDROXYPHENYL)COUMARIN 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

  • 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
  • PDM 2
  • 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
  • PDM-2;PDM2;PDM 2;688348-25-6
  • Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-
  • inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR
  • (E)-1,3-Dichloro-5-(4-chlorostyryl)benzene
  • 688348-25-6