Ethyl 1,4-Benzodioxan-2-carboxylate
- Product Name
- Ethyl 1,4-Benzodioxan-2-carboxylate
- CAS No.
- 4739-94-0
- Chemical Name
- Ethyl 1,4-Benzodioxan-2-carboxylate
- Synonyms
- TIMTEC-BB SBB008613;Doxazosin Impurity 2;Doxazosin Impurity 16;2,3-Dihydro-2-Carboethoxy-1,4-;ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE;ETHYL 1,4-BENZODIOXANE-2-CARBOXYLATE;Ethyl1,4-Benzodioxane-2-carboxylate>Ethyl 1,4-benzodioxan-2-carboxylate(EBDC);2,3-Dihydro-2-carboethoxy-1, 4-benzodioxane;1,4-BENZODIOXAN-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB4740922
- Molecular Formula
- C11H12O4
- Formula Weight
- 208.21
- MOL File
- 4739-94-0.mol
Ethyl 1,4-Benzodioxan-2-carboxylate Property
- Boiling point:
- 88-95 °C/0.3 mmHg (lit.)
- Density
- 1.208 g/mL at 25 °C
- refractive index
- n20/D 1.523
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Yellow to Orange
- InChI
- InChI=1S/C11H12O4/c1-2-13-11(12)10-7-14-8-5-3-4-6-9(8)15-10/h3-6,10H,2,7H2,1H3
- InChIKey
- DDIGEMWIKJMEIU-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2OCC1C(OCC)=O
- CAS DataBase Reference
- 4739-94-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E0902
- Product name
- Ethyl 1,4-Benzodioxane-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- E0902
- Product name
- Ethyl 1,4-Benzodioxane-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $341
- Updated
- 2025/07/31
- Product number
- D448235
- Product name
- 2,3-Dihydro-1,4-benzodioxin-2-carboxylicAcidEthylEster
- Packaging
- 25g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- D448235
- Product name
- 2,3-Dihydro-1,4-benzodioxin-2-carboxylicAcidEthylEster
- Packaging
- 50g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CHM0019371
- Product name
- 2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $648.81
- Updated
- 2021/12/16
Ethyl 1,4-Benzodioxan-2-carboxylate Chemical Properties,Usage,Production
Uses
2,3-Dihydro-1,4-benzodioxin-2-carboxylic Acid Ethyl Ester is an intermediate used to prepare presynaptic α2-adrenoreceptor antagonists and potential antidepressants. It is also used to prepare aminoalkylbenzodioxins as calcium antagonists.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5373, 1955 DOI: 10.1021/ja01625a050
Synthesis
120-80-9
3674-13-3
4739-94-0
GENERAL METHOD: A mixture of 12 g (0.11 mol) of catechol, 17.9 g (0.1 mol) of ethyl 2,3-dibromopropionate, and 41.4 g (0.3 mol) of anhydrous K2CO3 was refluxed for 18 hours in 200 mL of anhydrous acetone. Upon completion of the reaction, acetone was removed by distillation under reduced pressure and the residue was dissolved in dichloromethane. The organic phase was washed sequentially with water, 5% NaOH solution, 5% HCl solution and saturated NaCl solution and finally dried with anhydrous Na2SO4. After evaporating the solvent under reduced pressure, the residue was distilled to give 15.4 g (74% yield) of ethyl 1,4-benzodioxane-2-carboxylate.
References
[1] Sangita M. Kasture. “Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid.” Biochemical Engineering Journal 27 1 (2005): Pages 66-71.
Ethyl 1,4-Benzodioxan-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 1,4-Benzodioxan-2-carboxylate Suppliers
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- Fax
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- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
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- Ukraine
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View Lastest Price from Ethyl 1,4-Benzodioxan-2-carboxylate manufacturers
- Product
- Ethyl 1,4-Benzodioxane-2-carboxylate 4739-94-0
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-12
- Product
- Ethyl 1,4-benzodioxan-2-carboxylate(EBDC) 4739-94-0
- Price
- US $600.00-500.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kgs/20days
- Release date
- 2024-07-08
- Product
- ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE 4739-94-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24