1,4-Benzodioxan-2-carboxylic acid
- Product Name
- 1,4-Benzodioxan-2-carboxylic acid
- CAS No.
- 3663-80-7
- Chemical Name
- 1,4-Benzodioxan-2-carboxylic acid
- Synonyms
- 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid;Doxazosin EP IMpurity A;RX 811056;AKOS AUF2101;BUTTPARK 36\04-47;AKOS BBS-00006546;RARECHEM AL BO 1613;1,4-Benzodioxan-2-ca;Doxazosin Impurity 3;Doxazosin iMpurity A
- CBNumber
- CB5222957
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 3663-80-7.mol
1,4-Benzodioxan-2-carboxylic acid Property
- Melting point:
- 126-130 °C(lit.)
- Boiling point:
- 347.2±41.0 °C(Predicted)
- Density
- 1.379±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.69±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- 7.63g/L at 20℃
- λmax
- 282nm(MeOH)(lit.)
- InChI
- InChI=1S/C9H8O4/c10-9(11)8-5-12-6-3-1-2-4-7(6)13-8/h1-4,8H,5H2,(H,10,11)
- InChIKey
- HMBHAQMOBKLWRX-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2OCC1C(O)=O
- LogP
- 0.5 at 20℃
- CAS DataBase Reference
- 3663-80-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR3312
- Product name
- Doxazosin Related Compound D
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 50MG
- Price
- $588.05
- Updated
- 2025/07/31
- Product number
- 1225463
- Product name
- Doxazosin Related Compound D
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $1450
- Updated
- 2025/07/31
- Product number
- 561371
- Product name
- 1,4-Benzodioxan-2-carboxylic acid
- Purity
- 97%
- Packaging
- 25G
- Price
- $262
- Updated
- 2022/05/15
- Product number
- B3406
- Product name
- 1,4-Benzodioxane-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- B3406
- Product name
- 1,4-Benzodioxane-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $136
- Updated
- 2025/07/31
1,4-Benzodioxan-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White To Off-White Solid
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Flammability and Explosibility
Not classified
Synthesis
3663-82-9
3663-80-7
The general procedure for the synthesis of 4-benzodioxane-2-carboxylic acid from (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol was carried out as follows: (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol was accurately weighed and dissolved in 0.3 N aqueous KOH (1.3 equiv). Potassium permanganate (KMnO4, 2.0 eq.) was slowly added under ice bath conditions at 0 °C. The reaction mixture was stirred at low temperature for about 10 minutes and then transferred to room temperature to continue stirring overnight. Upon completion of the reaction, the organic phase was extracted with dichloromethane and subsequently washed with water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid as the crude product of 4-benzodioxane-2-carboxylic acid. The crude product was purified by silica gel fast column chromatography, and the final pure product was obtained in 92.5% yield.
References
[1] Patent: CN105985328, 2016, A. Location in patent: Paragraph 0063; 0071; 0072
1,4-Benzodioxan-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-Benzodioxan-2-carboxylic acid manufacturers
- Product
- 1,4-Benzodioxan-2-carboxylic acid 3663-80-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-12
- Product
- 1,4-Benzodioxan-2-carboxylic acid 3663-80-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-15
- Product
- 1,4-Benzodioxan-2-carboxylic acid 3663-80-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-28