(R)-1,4-Benzodioxane-2-carboxylic acid
- Product Name
- (R)-1,4-Benzodioxane-2-carboxylic acid
- CAS No.
- 70918-53-5
- Chemical Name
- (R)-1,4-Benzodioxane-2-carboxylic acid
- Synonyms
- UNII:T9Z56HV1B0;(R)-1,4-BENZODIOXAN 2-CARBOXYLIC ACID;(R)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID;(R)-1,4-Benzodioxane-2-carboxylic acid;(R)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-CARBOXYLIC ACID;(2R)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid;(3R)-2,3-Dihydro-1,4-benzodioxine-3-carboxylic acid;(R)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID;(R)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid;1,4-Benzodioxin-2-carboxylic acid, 2,3-dihydro-, (2R)-
- CBNumber
- CB4290760
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 70918-53-5.mol
(R)-1,4-Benzodioxane-2-carboxylic acid Property
- Melting point:
- 96-99 °C
- Boiling point:
- 347.2±41.0 °C(Predicted)
- alpha
- 83 º (c=1.5% in chloroform)
- Density
- 1.379±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.69±0.20(Predicted)
- form
- solid
- color
- Pale yellow
- optical activity
- [α]20/D +83±2°, c = 1.5% in chloroform
- BRN
- 5742837
- InChIKey
- HMBHAQMOBKLWRX-MRVPVSSYSA-N
- CAS DataBase Reference
- 70918-53-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B198705
- Product name
- (R)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylicAcid
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 2H21-1-R3
- Product name
- (R)-1,4-Benzodioxane-2-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 41441
- Product name
- (R)-1,4-Benzodioxane-2-carboxylicacid,99%(Chiralpurity)
- Purity
- 99%(Chiralpurity)
- Packaging
- 500MG
- Price
- $187.04
- Updated
- 2021/12/16
- Product number
- W8006
- Product name
- (R)-1,4-Benzodioxane-2-carboxylic acid
- Packaging
- 1g
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CCH0001309
- Product name
- (R)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $270.9
- Updated
- 2021/12/16
(R)-1,4-Benzodioxane-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
(R)-1,4-Benzodioxane-2-carboxylic acid is a chiral synthon mostly used in the preparation of doxazosin mesylate, a drug treating benign prostatic hyperplasia.
Synthesis
3663-82-9
3663-80-7
General procedure for the synthesis of 4-benzodioxane-2-carboxylic acid from (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol: Accurately weigh (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol, and dissolve it in 0.3 N aqueous KOH (1.3 equiv). Potassium permanganate (KMnO4, 2.0 eq.) was slowly added under ice bath conditions at 0 °C. The reaction mixture was first stirred at low temperature for about 10 minutes, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the organic phase was extracted with dichloromethane, the organic phase was washed with water sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a white solid, i.e., the crude product of 4-benzodioxane-2-carboxylic acid. The crude product was purified by silica gel fast column chromatography, and the final pure product was obtained in 92.5% yield.
References
[1] Patent: CN105985328, 2016, A. Location in patent: Paragraph 0063; 0071; 0072
(R)-1,4-Benzodioxane-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-1,4-Benzodioxane-2-carboxylic acid manufacturers
- Product
- (R)-1,4-Benzodioxane-2-carboxylic acid 70918-53-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08