(S)-1,4-Benzodioxane-2-carboxylic acid

Product Name: (S)-1,4-Benzodioxane-2-carboxylic acid
CAS No.: 70918-54-6
Chemical Name: (S)-1,4-Benzodioxane-2-carboxylic acid
Synonyms: AfaL;anine [INN];Afalanine [INN];(S)-1,4-BENZODIOXAN 2-CARBOXYLIC ACID;(S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID;(S)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-CARBOXYLIC ACID;(2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid;(3S)-2,3-Dihydro-1,4-benzodioxine-3-carboxylic acid;(S)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID;(S)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
CBNumber: CB9215993
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 70918-54-6.mol

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(S)-1,4-Benzodioxane-2-carboxylic acid Property

Melting point:: 96-99 °C
Boiling point:: 347.2±41.0 °C(Predicted)
alpha: -83 º (c=1.5% in chloroform)
Density: 1.379±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.69±0.20(Predicted)
Appearance: White to off-white Solid
optical activity: [α]20/D 83±2°, c = 1.5% in chloroform
BRN: 5742836

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B198710
Product name: (S)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylicAcid
Packaging: 2.5g
Price: $605
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD140110
Product name: (S)-2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD140110
Product name: (S)-2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
Packaging: 100mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: 0998AC
Product name: (S)-1,4-Benzodioxane-2-carboxylic acid
Packaging: 250mg
Price: $143
Updated: 2021/12/16

Apolloscientific

Product number: OR913812
Product name: (S)-1,4-Benzodioxane-2-carboxylic acid
Purity: 95%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

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(S)-1,4-Benzodioxane-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

(S)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylic Acid is an intermediate used to prepare 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents. It is also used to synthesize G protein-coupled receptor antagonists.

Synthesis

3663-82-9

3663-80-7

1. Weigh (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol (compound b) and dissolve in 0.3 N aqueous KOH (1.3 equiv). 2. KMnO4 (2.0 eq.) was slowly added at 0 °C. 3. The reaction mixture was stirred at low temperature for about 10 minutes, followed by stirring at room temperature overnight. 4. After completion of the reaction, the organic phase was extracted with dichloromethane. 5. The organic phase was washed with water and subsequently dried with anhydrous sodium sulfate and concentrated to give a white solid, the crude product of 4-benzodioxane-2-carboxylic acid (compound c). 6. The crude product was purified by rapid chromatography on silica gel in 92.5% yield.

References

[1] Patent: CN105985328, 2016, A. Location in patent: Paragraph 0063; 0071; 0072

(S)-1,4-Benzodioxane-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1,4-Benzodioxane-2-carboxylic acid Suppliers

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View Lastest Price from (S)-1,4-Benzodioxane-2-carboxylic acid manufacturers

Career Henan Chemical Co

Product: (S)-1,4-Benzodioxane-2-carboxylic acid 70918-54-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-09

70918-54-6, (S)-1,4-Benzodioxane-2-carboxylic acidRelated Search:

Terephthalic acid Benzoic acid Diallyl phthalate Bis(2-ethylhexyl) phthalate Diethyl phthalate Benzo[b]thien-2-ylboronic acid Folic acid Potassium hydrogen phthalate Dihydromyrcenol Ethyl 2-(Chlorosulfonyl)acetate Dimethyl phthalate Isophthalic acid Phthalic acid Benzyl benzoate Diisobutyl phthalate Ascoric Acid 2-HYDROXYMETHYL-1,4-BENZODIOXANE Anthranilic acid

(2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid

(S)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-CARBOXYLIC ACID

(S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID

(S)-1,4-BENZODIOXAN 2-CARBOXYLIC ACID

(S)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID

(S)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

Afalanine [INN]

(3S)-2,3-Dihydro-1,4-benzodioxine-3-carboxylic acid

AfaL

anine [INN]

1,4-Benzodioxin-2-carboxylic acid, 2,3-dihydro-, (2S)-

(2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid - [D87295]

70918-54-6

Asymmetric Synthesis

Chiral Resolving Reagents

Chiral Resolution Reagents