2,6-Dihydroxybenzaldehyde
- Product Name
- 2,6-Dihydroxybenzaldehyde
- CAS No.
- 387-46-2
- Chemical Name
- 2,6-Dihydroxybenzaldehyde
- Synonyms
- 2,6-DIHYDROXYBENZALDEHYDE;2,6-Dihydroxy Benzoldehyde;Benzaldehyde, 2,6-dihydroxy-;2,6-dihydroxybenzaldehyde(387-46-2)
- CBNumber
- CB4747901
- Molecular Formula
- C7H6O3
- Formula Weight
- 138.12
- MOL File
- 387-46-2.mol
2,6-Dihydroxybenzaldehyde Property
- Melting point:
- 154-155°C
- Boiling point:
- 223°C
- Density
- 1.409
- Flash point:
- 103°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.66±0.10(Predicted)
- color
- Pale Yellow to Light Yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C7H6O3/c8-4-5-6(9)2-1-3-7(5)10/h1-4,9-10H
- InChIKey
- DGXAGETVRDOQFP-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(O)C=CC=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D451015
- Product name
- 2,6-Dihydroxybenzaldehyde
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- D451015
- Product name
- 2,6-Dihydroxybenzaldehyde
- Packaging
- 2.5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- D451015
- Product name
- 2,6-Dihydroxybenzaldehyde
- Packaging
- 10g
- Price
- $520
- Updated
- 2021/12/16
- Product number
- CS-W001105
- Product name
- 2,6-Dihydroxybenzaldehyde
- Purity
- 99.75%
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- FD63326
- Product name
- 2,6-Dihydroxybenzaldehyde
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
2,6-Dihydroxybenzaldehyde Chemical Properties,Usage,Production
Uses
2,6-Dihydroxybenzaldehyde is a reactant used in the synthesis of cinnamides as potent cholinesterase inhibitors.
Definition
ChEBI: 2,6-dihydroxybenzaldehyde is a dihydroxybenzaldehyde.
Synthesis
3392-97-0
387-46-2
The general procedure for the synthesis of 2,6-dihydroxybenzaldehyde from 2,6-dimethoxybenzaldehyde was as follows: a dichloromethane (1200 mL) solution of AlCl3 (240 g, 1.80 mol, 3.00 eq.) was added to a 3000 mL three-necked round bottom flask. The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of a dichloromethane (800 mL) solution of 2,6-dimethoxybenzaldehyde (100 g, 601.78 mmol, 1.00 equiv). After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction was quenched with 200 mL of dilute hydrochloric acid (2 M). The reaction mixture was extracted with dichloromethane (2 x 200 mL). The organic layers were combined and concentrated under vacuum. The concentrated residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:200 to 1:50) as eluent to give 40 g (48% yield) of 2,6-dihydroxybenzaldehyde as a yellow solid. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.25 (s, 2H), 10.25 (s, 1H), 7.36 (m, 1H), 6.36 (d, J = 8.4 Hz, 2H); mass spectrum (ESI) m/z 139 [M + H]+.
References
[1] Green Chemistry, 2018, vol. 20, # 4, p. 804 - 808
[2] Chemistry - A European Journal, 2009, vol. 15, # 1, p. 125 - 135
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 14, p. 6772 - 6790
[4] Patent: CN105566276, 2016, A. Location in patent: Paragraph 0130; 0134; 0135; 0136
[5] Helvetica Chimica Acta, 2005, vol. 88, # 1, p. 120 - 153
2,6-Dihydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dihydroxybenzaldehyde manufacturers
- Product
- 2,6-Dihydroxybenzaldehyde 387-46-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 97.0%min；99.0%min
- Supply Ability
- 60KG/Batch
- Release date
- 2025-11-30
- Product
- 2,6-Dihydroxybenzaldehyde 387-46-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 2,6-Dihydroxybenzaldehyde 387-46-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-15