ChemicalBook > CAS DataBase List > 2-CYANO-3-METHOXYPYRIDINE

2-CYANO-3-METHOXYPYRIDINE

Product Name
2-CYANO-3-METHOXYPYRIDINE
CAS No.
24059-89-0
Chemical Name
2-CYANO-3-METHOXYPYRIDINE
Synonyms
3-METHOXYPICOLINONITRILE;2-CYANO-3-METHOXYPYRIDINE;3-Methoxy-2-Pyridinecarbonitrile;3-METHOXY-PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 3-methoxy-;2-CYANO-3-METHOXYPYRIDINE ISO 9001：2015 REACH
CBNumber
CB4760443
Molecular Formula
C7H6N2O
Formula Weight
134.14
MOL File
24059-89-0.mol
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2-CYANO-3-METHOXYPYRIDINE Property

Melting point:
111-112℃ (ethyl acetate )
Boiling point:
289.8±20.0℃ (760 Torr)
Density 
1.16±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:
129.1±21.8℃
storage temp. 
Inert atmosphere,Room Temperature
pka
-4?+-.0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
M219115
Product name
3-Methoxypyridine-2-carbonitrile
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
023712
Product name
2-Cyano-3-methoxypyridine
Purity
98%
Packaging
25g
Price
$377
Updated
2021/12/16
AK Scientific
Product number
V4606
Product name
3-methoxypyridine-2-carbonitrile
Packaging
1g
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
023712
Product name
2-Cyano-3-methoxypyridine
Purity
98%
Packaging
5g
Price
$124
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0080099
Product name
2-CYANO-3-METHOXYPYRIDINE
Purity
95.00%
Packaging
5G
Price
$818.9
Updated
2021/12/16
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2-CYANO-3-METHOXYPYRIDINE Chemical Properties,Usage,Production

Synthesis

124-41-4

38180-46-0

24059-89-0

Under nitrogen protection, sodium methanolate (0.41 g, 7.5 mmol) was dissolved in a 25 mL round bottom flask containing 10 mL of anhydrous N,N-dimethylformamide and the mixture was cooled to 4 °C using an ice water bath. Subsequently, 3-chloro-2-cyanopyridine (1.01 g, 7.2 mmol) was added to the reaction system, the ice-water bath was removed, and the reaction system was allowed to slowly warm up to 25 °C. After the reaction was carried out for 2 hours, the solvent was removed by vacuum concentration. Ethyl acetate was added to the concentrated residue and filtered to remove the insoluble precipitate. The filtrate was further concentrated on a rotary evaporator to afford the target product 2-cyano-3-methoxypyridine as a white solid (0.88 g, 88% yield), which could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 8.22 (dd, J = 7.4 and 1.6 Hz, 1H), 7.90 (dd, J = 7.5 and 7.3 Hz, 1H), 7.73 (dd, J = 7.73 and 1.6 Hz, 1H), 3.92 (s, 3H). Mass spectral analysis (ESI+) showed m/z (M + H)+ = 135.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5352 - 5359
[2] Patent: WO2015/187934, 2015, A1. Location in patent: Paragraph 0205

2-CYANO-3-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-3-METHOXYPYRIDINE Suppliers

Canada 1 China 74 India 1 United States 9 Global 85
Alchem Pharmtech,Inc.
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View Lastest Price from 2-CYANO-3-METHOXYPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-CYANO-3-METHOXYPYRIDINE 24059-89-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-15

24059-89-0, 2-CYANO-3-METHOXYPYRIDINERelated Search:

2-Pyridinecarbonitrile,5-amino-3-methoxy-(9CI) 2-CYANO-3-METHOXYPYRIDINE 3-methoxy-5-(trifluoromethyl)-2-pyridinecarbonitrile 3-(4-METHOXYPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(8-QUINOLINYLOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(4-CHLOROPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 5-(TRIFLUOROMETHYL)-3-[3-(TRIFLUOROMETHYL)PHENOXY]-2-PYRIDINECARBONITRILE 3-(4-[3-(DIMETHYLAMINO)ACRYLOYL]PHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(3-PYRIDINYLMETHOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-[(2-CHLOROBENZYL)OXY]-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(3-PYRIDINYLOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(4-CHLORO-2-METHYLPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-[4-(TERT-BUTYL)PHENOXY]-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(4-ACETYLPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(4-FLUOROPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 5-(TRIFLUOROMETHYL)-3-[4-(TRIFLUOROMETHYL)PHENOXY]-2-PYRIDINECARBONITRILE 3-(4-HYDROXYPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(3,5-DICHLOROPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE

  • 3-METHOXYPICOLINONITRILE
  • 3-METHOXY-PYRIDINE-2-CARBONITRILE
  • 3-Methoxy-2-Pyridinecarbonitrile
  • 2-CYANO-3-METHOXYPYRIDINE
  • 2-Pyridinecarbonitrile, 3-methoxy-
  • 2-CYANO-3-METHOXYPYRIDINE ISO 9001：2015 REACH
  • 24059-89-0