MART-1 (27-35) (human)

MART-1 (27-35) (human) Property

Boiling point:

1211.9±65.0 °C(Predicted)

Density 

1.184±0.06 g/cm3(Predicted)

storage temp. 

-15°C

form 

lyophilized powder

pka

3.32±0.10(Predicted)

color 

white

Water Solubility 

water, double-distilled: soluble

Hazard and Precautionary Statements (GHS)

MART-1 (27-35) (human) Chemical Properties,Usage,Production

Uses

MART-1 (27-35) (human) is an immunogenic epitope recognized by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TIL)[1].

Biological Activity

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.

References

[1] Kawakami Y, et al. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J Exp Med. 1994 Jul 1;180(1):347-52. DOI:10.1084/jem.180.1.347
[2] Nolte A, et al. Allogeneic Cell Therapy with Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Malignant Melanoma[M]//Transplantation in Hematology and Oncology II. Springer, Berlin, Heidelberg, 2003: 37-40.