Overview Side effects Mechanism of action Pharmacokinetics
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Yohimbine hydrochloride

Overview Side effects Mechanism of action Pharmacokinetics
Product Name
Yohimbine hydrochloride
CAS No.
65-19-0
Chemical Name
Yohimbine hydrochloride
Synonyms
YOHIMBINE HCL;YOHIMBE HCL;Corynante Yohimbe;Yobinol;Tosanpin;Yohydrol;GyniMbine;Menolysin;antagonil;Yuhengbin
CBNumber
CB4768636
Molecular Formula
C21H27ClN2O3
Formula Weight
390.9
MOL File
65-19-0.mol
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Yohimbine hydrochloride Property

Melting point:
288-290 °C (dec.)(lit.)
alpha 
99 º (c=1%, H2O, dry subst)
refractive index 
103 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 10 mg/mL
form 
powder
color 
white to off-white
optical activity
[α]/D 100±5°, c = 1 in H2O
Sensitive 
Light Sensitive
Merck 
14,10102
InChI
InChI=1/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/s3
InChIKey
PIPZGJSEDRMUAW-VJDCAHTMSA-N
SMILES
N1C2=C(C=CC=C2)C2=C1[C@@]1(C[C@]3([C@](CC[C@@H]([C@@H]3C(OC)=O)O)([H])CN1CC2)[H])[H].[H]Cl |&1:9,11,12,15,16,r|
LogP
2.201 (est)
CAS DataBase Reference
65-19-0(CAS DataBase Reference)
EPA Substance Registry System
Yohimbine hydrochloride (65-19-0)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-33-23/24
Safety Statements 
22-36/37/39-45-24/25
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
ZG1015000
TSCA 
Yes
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3265
Product name
Yohimbine Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL82685
Product name
Yohimbine hydrochloride
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$312
Updated
2024/03/01
Sigma-Aldrich
Product number
49768
Product name
Yohimbine hydrochloride
Purity
analytical standard
Packaging
50mg
Price
$97.3
Updated
2024/03/01
Sigma-Aldrich
Product number
1724000
Product name
Yohimbine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04777
Product name
Yohimbine Hydrochloride - CAS 65-19-0 - Calbiochem
Purity
Yohimbine Hydrochloride is a potent antagonist for α?-adrenoceptors, α2B and α2C receptors respectively).
Packaging
1G
Price
$63.1
Updated
2022/05/15
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Yohimbine hydrochloride Chemical Properties,Usage,Production

Overview

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). Oral and intravenous yohimbine causes an increase in MHPG and blood pressure in healthy human subjects (Charney et al., 1982d; Goldberg et al., 1986). Depressed patients demonstrate an increased cortisol and blood pressure response to intravenous yohimbine compared with healthy subjects, while plasma MHPG is not significantly different between the two groups of subjects (Heninger et al., 1988). The effects of acute or chronic antidepressant treatments on the neuroendocrine or behavioural responses to yohimbine in depressed patients have not been studied.

Side effects

Yohimbine hydrochloride has been associated with high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. It can be dangerous if taken in large doses or for long periods of time. It should not be taken in combination with monoamine oxidase (MAO) inhibitors, as effects may be additive.
Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, or phenothiazines. People with kidney problems and people with psychiatric conditions should not use yohimbe. Women who are pregnant or breastfeeding should not take yohimbe.
The Journal of Medical Toxicology reports an instance of refractory priapism associated with ingestion of yohimbe extract, and there are other scattered reports of adverse reactions. However, may studies report it to be generally well tolerated.

Mechanism of action

Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.

Pharmacokinetics

Yohimbine hydrochloride—an α2-adrenoceptor antagonist that is approved for treatment of erectile dysfunction—may increase BP.1,2,In normal volunteers and in patients with panic disorders, oral administration at doses used clinically may slightly increase BP.1 However, in hypertensive patients oral yohimbine was reported to induce a significant increase in mean arterial pressure.The magnitude of the pressor response was related to baseline norepinephrine levels and to the yohimbine-induced increment in plasma norepinephrine levels.Thus yohimbine increases BP by stimulation of the sympathetic nervous outflow, and the drug should be administered with caution to patients with evidence for increased basal sympathetic outflow or those undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

Chemical Properties

white to slightly yellow powder, slightly fragrant, slightly bitter taste, easily soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water.

Uses

Yohimbine hydrochloride is an Indole alkaloid with α2-adrenergic blocking activity. It is an alpha adrenergic blocker, mydriatic, antidepressant that used in the treatment of neurological disorders and erectile dysfunction.

Uses

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.

General Description

Yohimbine hydrochloride is an indole alkaloid derived from the tree bark. It is an antagonist of α2-adrenergic receptors in the brain, reducing the effects of xylazine, which is an α2-adrenergic agonis.

Biochem/physiol Actions

Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.

Veterinary Drugs and Treatments

Yohimbine is indicated to reverse the effects of xylazine in dogs, but it is being used clinically in several other species as well.
Yohimbine may be efficacious in reversing some of the toxic effects associated with other agents (e.g., amitraz) and can be used prophylactically before amitraz dips.

storage

Store at RT

Yohimbine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Yohimbine hydrochloride manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Yohimbine hydrochloride 65-19-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
1000KG
Release date
2022-09-22
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Yohimbine /Yohimbine HCl 65-19-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Yohimbine hydrochloride 65-19-0
Price
US $0.00/G
Min. Order
50G
Purity
98%min
Supply Ability
30KG/month
Release date
2023-01-31

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