ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE
- Product Name
- ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE
- CAS No.
- 128072-93-5
- Chemical Name
- ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE
- Synonyms
- ethyl 5-chloropicolinate;ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE;Ethyl 5-chloro-2-pyridinecarboxylate;5-Chloropyridine-2-carboxylic acid ethyl ester;2-Pyridinecarboxylic acid, 5-chloro-, ethyl ester;(5-CHLOROPYRIDINE)-2-CARBOXYLIC ACID ETHYL ESTER, 98+%;ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB4772950
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 128072-93-5.mol
ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE Property
- Melting point:
- 47-50°
- Boiling point:
- 263.4±20.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.46±0.10(Predicted)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- B125775
- Product name
- Ethyl5-Chloro-2-pyridinecarboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC150121
- Product name
- 5-Chloropyridine-2-carboxylic acid ethylester
- Packaging
- 50mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FC150121
- Product name
- 5-Chloropyridine-2-carboxylic acid ethylester
- Packaging
- 100mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- 046382
- Product name
- Ethyl 5-chloro-2-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 4H23-5-1Q
- Product name
- Ethyl 5-chloropyridine-2-carboxylate
- Packaging
- 500mg
- Price
- $154
- Updated
- 2021/12/16
ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
86873-60-1
64-17-5
128072-93-5
5-Chloropyridine-2-carboxylic acid (1.0 g, 6.35 mmol) was used as a raw material and it was mixed with concentrated HCl. H2SO4 (0.1 ml) and EtOH (10 ml) were added to the mixture and the reaction was subsequently heated at 80 °C for 16 hours. After completion of the reaction, the reaction mixture was cooled and concentrated under reduced pressure. The concentrated residue was dissolved in EtOAc (50 ml) and washed sequentially with saturated NaHCO3 solution (25 ml) and brine (25 ml). The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure to afford the target compound ethyl 5-chloropyridinecarboxylate (990 mg, 84% yield).LCMS analysis showed the calculated value of MH+ to be 186; the measured value was 98% (MH+) m/z 186 with retention time Rt=1.13 min.1H NMR (250 MHz, CDCl3) δ ppm: 8.63-8.76 (1H, m), 8.10 (1H, d, J=8.4Hz), 7.82 (1H, dd, J=8.5,2.4Hz), 4.49 (2H, q, J=7.2Hz), 1.45 (3H, t, J=7.2Hz).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 8, p. 3516 - 3540
[2] Patent: WO2009/135842, 2009, A1. Location in patent: Page/Page column 76
[3] Chemistry - A European Journal, 2014, vol. 20, # 13, p. 3610 - 3615
[4] Patent: WO2004/14902, 2004, A2. Location in patent: Page 42
[5] Patent: US2011/237791, 2011, A1. Location in patent: Page/Page column 66
ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE manufacturers
- Product
- ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE 128072-93-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06