5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
Uses- Product Name
- 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
- CAS No.
- 1224288-92-9
- Chemical Name
- 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
- Synonyms
- 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile;5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-chloro-
- CBNumber
- CB62682231
- Molecular Formula
- C7H3ClN4
- Formula Weight
- 178.58
- MOL File
- 1224288-92-9.mol
5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Property
- Melting point:
- 138-142℃ (isopropanol )
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.08±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H3ClN4/c8-6-1-2-12-7(11-6)5(3-9)4-10-12/h1-2,4H
- InChIKey
- OYGONYREIXSORZ-UHFFFAOYSA-N
- SMILES
- C12=C(C#N)C=NN1C=CC(Cl)=N2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381263
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C381263
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- C381263
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- C381263
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- OR918489
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Chemical Properties,Usage,Production
Uses
5-chloropyrazole[1,5-A]pyrimidine-3-carboxynitrile can be used in organic synthesis, pharmaceutical intermediates, etc.
Synthesis
1224288-95-2
1224288-92-9
General procedure for the synthesis of 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile from 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile: 5-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (10.00 g, 62.45 mmol) was mixed with phosphorus triclosamide (200.00 mL), heated to 150 °C, and the reaction took 4 hour. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio petroleum ether: ethyl acetate = 1:1). Upon completion of the reaction, the excess of phosphorous trichloride was removed by distillation under reduced pressure, and the residue was dissolved in dichloromethane and concentrated again. Finally, it was purified by silica gel column chromatography (eluent was dichloromethane) to afford 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile (6.00 g, yield 53.80%) as a white solid.
References
[1] Patent: WO2017/87778, 2017, A1. Location in patent: Page/Page column 27; 28
5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile manufacturers
- Product
- 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile 1224288-92-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile 1224288-92-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 100kg
- Release date
- 2020-01-09