ChemicalBook > CAS DataBase List > 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile

5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile

Uses

Product Name: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
CAS No.: 1224288-92-9
Chemical Name: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
Synonyms: 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile;5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-chloro-
CBNumber: CB62682231
Molecular Formula: C7H3ClN4
Formula Weight: 178.58
MOL File: 1224288-92-9.mol

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5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Property

Melting point:: 138-142℃ (isopropanol )
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.08±0.40(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C7H3ClN4/c8-6-1-2-12-7(11-6)5(3-9)4-10-12/h1-2,4H
InChIKey: OYGONYREIXSORZ-UHFFFAOYSA-N
SMILES: C12=C(C#N)C=NN1C=CC(Cl)=N2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C381263
Product name: 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Packaging: 25mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C381263
Product name: 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Packaging: 50mg
Price: $95
Updated: 2021/12/16

TRC

Product number: C381263
Product name: 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Packaging: 250mg
Price: $250
Updated: 2021/12/16

TRC

Product number: C381263
Product name: 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Packaging: 100mg
Price: $145
Updated: 2021/12/16

Apolloscientific

Product number: OR918489
Product name: 5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Purity: 98%
Packaging: 250mg
Price: $175
Updated: 2021/12/16

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5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Chemical Properties,Usage,Production

Uses

5-chloropyrazole[1,5-A]pyrimidine-3-carboxynitrile can be used in organic synthesis, pharmaceutical intermediates, etc.

Synthesis

1224288-95-2

1224288-92-9

General procedure for the synthesis of 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile from 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile: 5-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (10.00 g, 62.45 mmol) was mixed with phosphorus triclosamide (200.00 mL), heated to 150 °C, and the reaction took 4 hour. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio petroleum ether: ethyl acetate = 1:1). Upon completion of the reaction, the excess of phosphorous trichloride was removed by distillation under reduced pressure, and the residue was dissolved in dichloromethane and concentrated again. Finally, it was purified by silica gel column chromatography (eluent was dichloromethane) to afford 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile (6.00 g, yield 53.80%) as a white solid.

References

[1] Patent: WO2017/87778, 2017, A1. Location in patent: Page/Page column 27; 28

5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile 1224288-92-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile 1224288-92-9
Price: US $1.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100kg
Release date: 2020-01-09

1224288-92-9, 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrileRelated Search:

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5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile

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1224288-92-9