E3 ligase Ligand 18

Product Name: E3 ligase Ligand 18
CAS No.: 2241669-88-3
Chemical Name: E3 ligase Ligand 18
Synonyms: E3 ligase Ligand 18;L-Cysteine, N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-;(R)-2-Acetamido-3-((2-amino-9-(4-chlorobenzyl)-6-oxo-6,9-dihydro-3H-purin-8-yl)thio)propanoic acid;(2R)-3-({2-amino-9-[(4-chlorophenyl)methyl]-6-oxo-6,9-dihydro-3H-purin-8-yl}sulfanyl)-2-acetamidopropanoic acid
CBNumber: CB48054708
Molecular Formula: C17H17ClN6O4S
Formula Weight: 436.87
MOL File: 2241669-88-3.mol

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E3 ligase Ligand 18 Property

Density: 1.68±0.1 g/cm3(Predicted)
pka: 3.17±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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E3 ligase Ligand 18 Chemical Properties,Usage,Production

Uses

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

IC 50

Cereblon

References

[1] Heterocyclic compound. WO2018143403A1.

E3 ligase Ligand 18 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand 18 Suppliers

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2241669-88-3, E3 ligase Ligand 18Related Search:

E3 ligase Ligand 10 L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- E3 ligase Ligand 14 rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

E3 ligase Ligand 18

L-Cysteine, N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-

(2R)-3-({2-amino-9-[(4-chlorophenyl)methyl]-6-oxo-6,9-dihydro-3H-purin-8-yl}sulfanyl)-2-acetamidopropanoic acid

(R)-2-Acetamido-3-((2-amino-9-(4-chlorobenzyl)-6-oxo-6,9-dihydro-3H-purin-8-yl)thio)propanoic acid

2241669-88-3