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Pamrevlumab

Product Name
Pamrevlumab
CAS No.
946415-13-0
Chemical Name
Pamrevlumab
Synonyms
FG-3019;Pamrevlumab;Pamrevlumab (anti-CTGF);Research Grade Pamrevlumab;Research Grade Pamrevlumab(DHD82301)
CBNumber
CB48080941
Formula Weight
0
MOL File
Mol file
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Pamrevlumab Property

form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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Pamrevlumab Chemical Properties,Usage,Production

Uses

FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].

in vivo

FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) in combination with Gemcitabine acutely decreases mouse pancreatic ductal adenocarcinoma (PDA) growth and induces neoplastic cell apoptosis in LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice[2].

References

[1] Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. DOI:10.1080/13543784.2020.1773790
[2] Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. DOI:10.1073/pnas.1300415110

Pamrevlumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Pamrevlumab Suppliers

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946415-13-0, PamrevlumabRelated Search:


  • Pamrevlumab
  • Research Grade Pamrevlumab(DHD82301)
  • Research Grade Pamrevlumab
  • Pamrevlumab (anti-CTGF)
  • FG-3019
  • 946415-13-0