N1-Methyl-Pseudouridine-5'-Triphosphate

Color Form

Product Name: N1-Methyl-Pseudouridine-5'-Triphosphate
CAS No.: 1428903-59-6
Chemical Name: N1-Methyl-Pseudouridine-5'-Triphosphate
Synonyms: abs60156;N1-Me-pUTP;Pseudo-UTP-Na3;N1 -Me-Pseudo UTP;N1-Methylpseudo-UTP;N1-Methy-Pseudo-UTP;Cytidine Impurity 9;N1-Me-pUTP Tris salt;N1-Me-pUTP Sodium Salt;N1-Me-pUTP sodium solution
CBNumber: CB48099851
Molecular Formula: C10H17N2O15P3
Formula Weight: 498.17
MOL File: 1428903-59-6.mol

More

Less

N1-Methyl-Pseudouridine-5'-Triphosphate Property

Density: 2.010±0.06 g/cm3(Predicted)
pka: 0.97±0.50(Predicted)
InChI: InChI=1/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,8+/s3
InChIKey: OLRONOIBERDKRE-CAYFCZNJNA-N
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r|

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N1-Methyl-Pseudouridine-5'-Triphosphate Chemical Properties,Usage,Production

Color

N1-Methyl-Pseudouridine-5'-Triphosphate is a colorless to slightly yellow.

Form

N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water.

Description

N1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.

Uses

1-Methylpseudouridine-5'-triphosphate Sodium Salt is a salt analogue of 1-Methylpseudouridine-5'-triphosphate, which can be used to optimize the cardiac delivery of modified mRNA

Advantages

The substitution of U with N1-Methyl-Pseudouridine-5'-Triphosphate (m1Ψ) not only bypasses immune response induced cytotoxicity, but also substantially enhances the effectiveness of both types of switches. The m1Ψ substitution induced higher protein expression of mRNA than other modified bases, allowing clearer detection of signals and better fold-change between ON and OFF states of the switches. In addition, the m1Ψ substitution enhanced the sensitivity and performance of synthetic RNA circuit composed of both miRNA- and RBP-sensing switches[1].

References

[1] Callum J C Parr. “N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.” Nucleic Acids Research 48 6 (2020): e35.

N1-Methyl-Pseudouridine-5'-Triphosphate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N1-Methyl-Pseudouridine-5'-Triphosphate Suppliers

China 51 United States 3 USA 1 Global 55

Hefei Stongbio Co.,Ltd.

Tel: 15555170917
Email: sales@stongbio.com
Country: China
ProdList: 457
Advantage: 58

Wuhan Tangzhi Pharmaceutical Co., Ltd.

Tel: 027-63498076 13658392159
Email: sale@glycogene.com
Country: China
ProdList: 480
Advantage: 58

Nugene Biopharm Science (Hangzhou) Co., Ltd.

Tel: 13326014885
Email: service@nugene.com.cn
Country: China
ProdList: 51
Advantage: 58

Jiangsu Synthgene Biotechnology Co.,Ltd.

Tel: 18136497538
Email: znf@syngenebio.com
Country: China
ProdList: 901
Advantage: 58

Hefei Huana Biomedical Technology Co.,Ltd

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn
Country: China
ProdList: 95
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3661
Advantage: 58

Changsha Morning Shine Co., Ltd.

Tel: 13397510867
Email: dingningjing@csmspharm.com
Country: China
ProdList: 187
Advantage: 58

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9900
Advantage: 58

Shanghai AECOM Biotechnology Co. , Ltd.

Tel: 021-021-20956531 18116226605
Fax: 021-20956532
Email: sui@neosunpharm.com
Country: China
ProdList: 350
Advantage: 55

Tianjin Scaxchem Limited Compnay

Tel: 022-022-25327698 18920479040
Email: sales@cosychem.com
Country: China
ProdList: 583
Advantage: 55

More

Less

View Lastest Price from N1-Methyl-Pseudouridine-5'-Triphosphate manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Pseudo-UTP-Na3 1428903-59-6
Price: US $0.00/ml
Min. Order: 100ml
Purity: HPLC：≥90.0%
Supply Ability: 500L
Release date: 2024-02-06

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N1-Methyl-Pseudouridine-5'-Triphosphate 1428903-59-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1kg/month
Release date: 2023-01-13

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N1-methyl-Pseudo-UTP
Price: US $0.00/ml
Min. Order: 100ml
Purity: ≥99%(HPLC)
Supply Ability: 20000L
Release date: 2023-03-09

1428903-59-6, N1-Methyl-Pseudouridine-5'-TriphosphateRelated Search:

2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl-

N1-Methylpseudo-UTP

N1-Methylpseudouridine-5'-triphosphate

N1-Methyl-Pseudouridine-5'-Triphosphate 100mM solution

N1-Methy-Pseudo-UTP.3Na 100mM solution

N1-Methyl Pseudouridine-5'-Triphosphate, Trisodium Salt

abs60156

N1-Me-pUTP

1-Methylpseudouridine-5'-Triphosphate Trisodium salt

1-Methylpseudouridine-5'-Triphosphate sodium salt

N1-Me-Pseudo-UTP.3Na 100mM solution

N1 -Me-Pseudo UTP

N-Methyl pseudouridine Triphosphate, Trisodium Salt

N1-methyl-pseudouridine 5'-triphosphate, trisodium salt 100mM aqueous solution

N1-Methy-Pseudo-UTP

N1-Me-pUTP sodium solution

Cytidine Impurity 9

2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl-

N1-Methyl-Pseudouridine TP

N1-Me-pUTP Tris salt

N1-Me-pUTP Sodium Salt

N1-Me-pUTP 100mM Tris Solution

N1-Me-pUTP 200mM Tris Solution, GMP grade

N1-Me-pUTP 100mM Sodium Solution, GMP grade

N1-Me-pUTP 100mM Sodium Solution

1-Methyl pseudouridine Triphosphate, Trisodium Salt

Pseudo-UTP-Na3

N1-Me-Pseudo UTP Trisodium solution

N1-Me-Pseudo-UTP, 100mM Solution

1428903-59-6

Pharmaceutical

Nucleotide

Coronavirus