BENZOTHIOPHENE-4-CARBOXYLIC ACID
- Product Name
- BENZOTHIOPHENE-4-CARBOXYLIC ACID
- CAS No.
- 10134-95-9
- Chemical Name
- BENZOTHIOPHENE-4-CARBOXYLIC ACID
- Synonyms
- Fs002050;AKOS BC-0215;4-Benzothiophenecarboxylic acid;BENZOTHIOPHENE-4-CARBOXYLIC ACID;1-benzothiophene-4-carboxylic acid;Benzo[b]thiophene-4-carboxylic acid;BENZO[B]THIOPHENE-7-CARBOXYLIC ACID
- CBNumber
- CB4816146
- Molecular Formula
- C9H6O2S
- Formula Weight
- 178.21
- MOL File
- 10134-95-9.mol
BENZOTHIOPHENE-4-CARBOXYLIC ACID Property
- Melting point:
- 188-189℃
- Boiling point:
- 376.2±15.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- 3.34±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB142272
- Product name
- Benzo[b]thiophene-4-carboxylic acid
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- OR400932
- Product name
- Benzo[b]thiophene-4-carboxylic acid
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 6H21-1-0B
- Product name
- Benzo[b]thiophene-4-carboxylic acid
- Packaging
- 250mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FB142272
- Product name
- Benzo[b]thiophene-4-carboxylic acid
- Packaging
- 250mg
- Price
- $167.5
- Updated
- 2021/12/16
- Product number
- 119518
- Product name
- Benzo[b]thiophene-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $274
- Updated
- 2021/12/16
BENZOTHIOPHENE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
5118-13-8
124-38-9
10134-95-9
Benzo[b]thiophene-4-carboxylic acid was prepared as follows: a small amount of iodine crystals was added as initiator to a stirring suspension of magnesium (Mg, 4.79 g, 197 mmol) in anhydrous tetrahydrofuran (THF, 100 mL) under nitrogen protection. Subsequently, a solution of 4-bromobenzo[b]thiophene (40.0 g, 188 mmol) in anhydrous THF (150 mL) was added slowly and dropwise. Initially, only 5% of the total amount (~1 mL) was added to initiate the reaction, after which the remaining solution was added at a rate that maintained the reaction temperature at 50-55 °C, a process that took about 30 min. After addition, the reaction mixture was continued to be stirred at 50°C for 1 hour. After most of the magnesium has been consumed, the reaction is cooled to 23°C and carbon dioxide (CO2) gas produced from dry ice is passed into the solution. The reaction is exothermic and the solution temperature needs to be maintained at about 23°C by an ice bath. The gas is continuously vented for 15-20 minutes until a large amount of precipitate generation is observed. Upon completion of the reaction, the reaction is carefully quenched with 10% aqueous hydrochloric acid (HCl) solution at 0°C. Saturated aqueous sodium chloride solution was added and the mixture was extracted with ethyl acetate (EtOAc). The organic phase was extracted with 2 M aqueous sodium hydroxide (NaOH) and subsequently the aqueous phase was acidified to pH 1 with 37% aqueous HCl to form a suspension. After filtration and drying, benzo[b]thiophene-4-carboxylic acid was obtained as a white solid (24.9 g, 74% yield).
References
[1] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 18
BENZOTHIOPHENE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BENZOTHIOPHENE-4-CARBOXYLIC ACID manufacturers
- Product
- BENZOTHIOPHENE-4-CARBOXYLIC ACID 10134-95-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11